MicroRNA Targeted Cancer Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook MicroRNA Targeted Cancer Therapy write by Fazlul H. Sarkar. This book was released on 2014-04-22. MicroRNA Targeted Cancer Therapy available in PDF, EPUB and Kindle. Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy” and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.
MicroRNAs: Key Regulators of Oncogenesis
MicroRNAs: Key Regulators of Oncogenesis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook MicroRNAs: Key Regulators of Oncogenesis write by Sadegh Babashah. This book was released on 2014-07-08. MicroRNAs: Key Regulators of Oncogenesis available in PDF, EPUB and Kindle. Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.
MicroRNAs in Cancer
MicroRNAs in Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook MicroRNAs in Cancer write by Cesar Lopez-Camarillo. This book was released on 2013-02-22. MicroRNAs in Cancer available in PDF, EPUB and Kindle. MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and th
MicroRNAs in Development and Cancer
MicroRNAs in Development and Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook MicroRNAs in Development and Cancer write by Frank J. Slack. This book was released on 2011. MicroRNAs in Development and Cancer available in PDF, EPUB and Kindle. MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.
MicroRNAs in Cancer
MicroRNAs in Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook MicroRNAs in Cancer write by César López-Camarillo. This book was released on 2013-02-22. MicroRNAs in Cancer available in PDF, EPUB and Kindle. MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets as well as the potential use in translational medicine. Chapters present comprehensive and expert perspectives on the roles of miRNAs in most common cancers from bench to bedside applications and are written by an international team of renowned experts in the field.
