Miniaturized, Label Free Optical Systems for Imaging Brain Hemodynamics

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Release : 2017
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Miniaturized, Label Free Optical Systems for Imaging Brain Hemodynamics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Miniaturized, Label Free Optical Systems for Imaging Brain Hemodynamics write by Iliya Sigal. This book was released on 2017. Miniaturized, Label Free Optical Systems for Imaging Brain Hemodynamics available in PDF, EPUB and Kindle. This dissertation focuses on instrumentation development for optical monitoring of hemodynamics in rodent brains, which would allow neurophysiologists, conducting pre-clinical research on brain diseases and disorders, to better understand disease onset and progression, and evaluate treatment options. Three specific challenges in applying optical tools to brain imaging were addressed: (1) the limited robustness of optical imaging in the presence of misfocus, (2) the low sensitivity in imaging brain activity under anaesthesia in chronic, longitudinal studies, and (3) the limited penetration depth of optical microscopy in tissue. Two methods were proposed to address misfocus-related imaging artefacts, which enable quantitative optical measurements of blood flow to take place across large fields of view and over long imaging time-frames. A system for blood flow monitoring with extended depth of field was developed, showing improved ability to accurately image flow speeds over large areas in the brain. In addition, a novel measure for misfocus was proposed, enabling robust autofocusing in the presence of measurement noise. A miniaturized, skull-mounted multi-modal optical imaging system was designed for imaging brain blood flow and oxygenation changes in freely-behaving animals. This device constituted the first demonstration of wide-field optical imaging of brain blood flow and oxygenation in a chronic setting, suitable for longitudinal studies of brain disease progression and investigating treatment efficacy. Lastly, a novel endoscopy method was proposed to measure flow speeds of scattering fluids through a single, multi-mode optical fiber. This endoscopy method could enable imaging blood flow speeds in deep brain structures using a minimally-invasive probe that is over 2x smaller than conventional micro-endoscopes used today. Combined, the accomplishments described in this dissertation contributed to making optical measurements of brain hemodynamics applicable to a wider range of imaging assays, and to making optical imaging a more accessible tool for the study of brain vasculature.

Wearable Antennas and Electronics

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Release : 2022-01-31
Genre : Technology & Engineering
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Book Rating : 240/5 ( reviews)

Wearable Antennas and Electronics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Wearable Antennas and Electronics write by Asimina Kiourti. This book was released on 2022-01-31. Wearable Antennas and Electronics available in PDF, EPUB and Kindle. This book presents a practical and comprehensive guide to game-changing and state-of-the-art wearable antennas and RF electronics and their applications. Written by leading experts, the book details how to weave clothing into functional antennas and sensors to serve as unobtrusive devices for medical monitoring, athletic performance tracking, body-area network communications, and a host of other applications. You will learn about the latest advances in materials and electronics along with new and unexplored opportunities in functionalizing fabrics for sensing and wireless connectivity; understand materials selection for diverse wearable applications; gain practical insight into the newest class of embroidered e-textiles; and learn how to engineer flexible and wearable sensors. Wearable Antennas and Electronics covers basic approaches for wearable technology and their applications. You will also get an expert preview of promising future directions and paths for research opportunities. This is a must-have resource for anyone working in the growing industry of wearables and body-area devices, including engineers, researchers, faculty, and graduate students.

Transpathology

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Release : 2024-06-25
Genre : Science
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Book Rating : 240/5 ( reviews)

Transpathology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Transpathology write by Mei Tian. This book was released on 2024-06-25. Transpathology available in PDF, EPUB and Kindle. Transpathology: Molecular Imaging-Based Pathology is a multidisciplinary reference on molecular imaging and pathology. The book is intended for professionals in the fields of molecular imaging, nuclear medicine, radiology, and pathology as well as students and clinical residents. The book describes the importance of non-invasive diagnosis-based precision medicine and presents a detailed description of current transpathological approaches in different aspects essential for the future development of precision medicine. It’s molecular imaging approach to experimental research and clinical practice will drive the field forward and improve research outcomes. Introduces a new concept of molecular imaging-guided precise biopsy Links in vivo and ex vivo information at various scales by using multi-modality imaging technologies Integrates future technologies for the non-invasive cross-validation of underlying mechanisms

Handbook of Neurophotonics

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Release : 2020-05-10
Genre : Science
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Book Rating : 900/5 ( reviews)

Handbook of Neurophotonics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Handbook of Neurophotonics write by Francesco S. Pavone. This book was released on 2020-05-10. Handbook of Neurophotonics available in PDF, EPUB and Kindle. The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 32 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain. Key Features: Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels. Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice. Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging. Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.

Biomedical Photoacoustics

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Book Rating : 119/5 ( reviews)

Biomedical Photoacoustics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biomedical Photoacoustics write by Wenfeng Xia. This book was released on . Biomedical Photoacoustics available in PDF, EPUB and Kindle.