Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics write by Panos Macheras. This book was released on 2006-04-26. Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics available in PDF, EPUB and Kindle. This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
Basic Pharmacokinetics and Pharmacodynamics
Basic Pharmacokinetics and Pharmacodynamics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Basic Pharmacokinetics and Pharmacodynamics write by Sara E. Rosenbaum. This book was released on 2016-11-22. Basic Pharmacokinetics and Pharmacodynamics available in PDF, EPUB and Kindle. Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out ... and also for use as a reference book ...." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD .... “ (British Toxicology Society Newsletter)
Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations
Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations write by Sheila Annie Peters. This book was released on 2012-02-17. Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations available in PDF, EPUB and Kindle. The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void. Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. Comprised of two parts, the book first provides a detailed and systematic treatment of the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics. The second part looks in greater detail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for a brief overview of the field as well as those who need more detail, the book includes a range of important learning aids. Featuring end-of-chapter keywords for easy reference a valuable asset for general or novice readers without a PBPK background along with an extensive bibliography for those looking for further information, Physiologically- Based Pharmacokinetic (PBPK) Modeling and Simulations is the essential single-volume text on one of the hottest topics in the pharmaceutical sciences today.
Pharmacometrics
Pharmacometrics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pharmacometrics write by Ene I. Ette. This book was released on 2013-03-14. Pharmacometrics available in PDF, EPUB and Kindle. Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians. Edited and written by key leaders in the field, this flagship text on pharmacometrics: Integrates theory and practice to let the reader apply principles and concepts. Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field. Is unique in including computer code information with the examples. This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.
Pharmacokinetics and Pharmacodynamics of Biotech Drugs
Pharmacokinetics and Pharmacodynamics of Biotech Drugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pharmacokinetics and Pharmacodynamics of Biotech Drugs write by Bernd Meibohm. This book was released on 2006-12-13. Pharmacokinetics and Pharmacodynamics of Biotech Drugs available in PDF, EPUB and Kindle. This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim. The result is vital reading for all pharmaceutical researchers.
