Modeling Parkinson's Disease: Bridging the Translational Gap - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Modeling Parkinson's Disease: Bridging the Translational Gap write by Graziella Madeo. This book was released on 2019-11-26. Modeling Parkinson's Disease: Bridging the Translational Gap available in PDF, EPUB and Kindle.
Bridging the gap in Parkinson ́s disease: novel fabrication methods for its modeling and treatment
Bridging the gap in Parkinson ́s disease: novel fabrication methods for its modeling and treatment - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Bridging the gap in Parkinson ́s disease: novel fabrication methods for its modeling and treatment write by . This book was released on . Bridging the gap in Parkinson ́s disease: novel fabrication methods for its modeling and treatment available in PDF, EPUB and Kindle.
Improving the Utility and Translation of Animal Models for Nervous System Disorders
Improving the Utility and Translation of Animal Models for Nervous System Disorders - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Improving the Utility and Translation of Animal Models for Nervous System Disorders write by Institute of Medicine. This book was released on 2013-04-25. Improving the Utility and Translation of Animal Models for Nervous System Disorders available in PDF, EPUB and Kindle. Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
Guidance for the Description of Animal Research in Scientific Publications
Guidance for the Description of Animal Research in Scientific Publications - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Guidance for the Description of Animal Research in Scientific Publications write by National Research Council. This book was released on 2011-09-16. Guidance for the Description of Animal Research in Scientific Publications available in PDF, EPUB and Kindle. The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.
Clinical Trials In Parkinson's Disease
Clinical Trials In Parkinson's Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Clinical Trials In Parkinson's Disease write by Santiago Perez-Lloret. This book was released on 2020-08-19. Clinical Trials In Parkinson's Disease available in PDF, EPUB and Kindle. This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.
