Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods write by Sandeep Menon. This book was released on 2015-12-09. Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods available in PDF, EPUB and Kindle. This book covers domains of modern clinical trial design: classical, group sequential, adaptive, and Bayesian methods applicable to and used in various phases of pharmaceutical development. Written for biostatisticians, pharmacometricians, clinical developers, and statistical programmers involved in the design, analysis, and interpretation of clinical trials, as well as students in graduate and postgraduate programs in statistics or biostatistics, it covers topics including: dose-response and dose-escalation designs; sequential methods to stop trials early for overwhelming efficacy, safety, or futility; Bayesian designs incorporating historical data; adaptive sample size re-estimation and randomization to allocate subjects to effective treatments; population enrichment designs. Methods are illustrated using clinical trials from diverse therapeutic areas, including dermatology, endocrinology, infectious disease, neurology, oncology and rheumatology. --
Bayesian Adaptive Methods for Clinical Trials
Bayesian Adaptive Methods for Clinical Trials - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Bayesian Adaptive Methods for Clinical Trials write by Scott M. Berry. This book was released on 2010-07-19. Bayesian Adaptive Methods for Clinical Trials available in PDF, EPUB and Kindle. Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer's disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adapti
Analysis of Clinical Trials Using SAS
Analysis of Clinical Trials Using SAS - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Analysis of Clinical Trials Using SAS write by Alex Dmitrienko. This book was released on 2017-07-17. Analysis of Clinical Trials Using SAS available in PDF, EPUB and Kindle. Analysis of Clinical Trials Using SAS®: A Practical Guide, Second Edition bridges the gap between modern statistical methodology and real-world clinical trial applications. Tutorial material and step-by-step instructions illustrated with examples from actual trials serve to define relevant statistical approaches, describe their clinical trial applications, and implement the approaches rapidly and efficiently using the power of SAS. Topics reflect the International Conference on Harmonization (ICH) guidelines for the pharmaceutical industry and address important statistical problems encountered in clinical trials. Commonly used methods are covered, including dose-escalation and dose-finding methods that are applied in Phase I and Phase II clinical trials, as well as important trial designs and analysis strategies that are employed in Phase II and Phase III clinical trials, such as multiplicity adjustment, data monitoring, and methods for handling incomplete data. This book also features recommendations from clinical trial experts and a discussion of relevant regulatory guidelines. This new edition includes more examples and case studies, new approaches for addressing statistical problems, and the following new technological updates: SAS procedures used in group sequential trials (PROC SEQDESIGN and PROC SEQTEST) SAS procedures used in repeated measures analysis (PROC GLIMMIX and PROC GEE) macros for implementing a broad range of randomization-based methods in clinical trials, performing complex multiplicity adjustments, and investigating the design and analysis of early phase trials (Phase I dose-escalation trials and Phase II dose-finding trials) Clinical statisticians, research scientists, and graduate students in biostatistics will greatly benefit from the decades of clinical research experience and the ready-to-use SAS macros compiled in this book.
Adaptive Design Theory and Implementation Using SAS and R, Second Edition
Adaptive Design Theory and Implementation Using SAS and R, Second Edition - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Adaptive Design Theory and Implementation Using SAS and R, Second Edition write by Mark Chang. This book was released on 2014-12-01. Adaptive Design Theory and Implementation Using SAS and R, Second Edition available in PDF, EPUB and Kindle. Get Up to Speed on Many Types of Adaptive Designs Since the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the use of various adaptive design methods in clinical trials. New to the Second Edition Twelve new chapters covering blinded and semi-blinded sample size reestimation design, pick-the-winners design, biomarker-informed adaptive design, Bayesian designs, adaptive multiregional trial design, SAS and R for group sequential design, and much more More analytical methods for K-stage adaptive designs, multiple-endpoint adaptive design, survival modeling, and adaptive treatment switching New material on sequential parallel designs with rerandomization and the skeleton approach in adaptive dose-escalation trials Twenty new SAS macros and R functions Enhanced end-of-chapter problems that give readers hands-on practice addressing issues encountered in designing real-life adaptive trials Covering even more adaptive designs, this book provides biostatisticians, clinical scientists, and regulatory reviewers with up-to-date details on this innovative area in pharmaceutical research and development. Practitioners will be able to improve the efficiency of their trial design, thereby reducing the time and cost of drug development.
Adaptive Design Theory and Implementation Using SAS and R
Adaptive Design Theory and Implementation Using SAS and R - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Adaptive Design Theory and Implementation Using SAS and R write by Mark Chang. This book was released on 2012-10-09. Adaptive Design Theory and Implementation Using SAS and R available in PDF, EPUB and Kindle. Adaptive design has become an important tool in modern pharmaceutical research and development. Compared to a classic trial design with static features, an adaptive design allows for the modification of the characteristics of ongoing trials based on cumulative information. Adaptive designs increase the probability of success, reduce costs and the t
