Molecular Basis of Specificity in Nucleic Acid-Drug Interactions - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Basis of Specificity in Nucleic Acid-Drug Interactions write by A. Pullman. This book was released on 2012-12-06. Molecular Basis of Specificity in Nucleic Acid-Drug Interactions available in PDF, EPUB and Kindle. One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.
DNA-targeting Molecules as Therapeutic Agents
DNA-targeting Molecules as Therapeutic Agents - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook DNA-targeting Molecules as Therapeutic Agents write by Michael J. Waring. This book was released on 2018-03-12. DNA-targeting Molecules as Therapeutic Agents available in PDF, EPUB and Kindle. There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
Molecular Aspects of Anticancer Drug DNA Interaction
Molecular Aspects of Anticancer Drug DNA Interaction - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Aspects of Anticancer Drug DNA Interaction write by Neidle. This book was released on 1993-08-16. Molecular Aspects of Anticancer Drug DNA Interaction available in PDF, EPUB and Kindle. This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
Molecular Aspects of Anticancer Drug DNA Interactions
Molecular Aspects of Anticancer Drug DNA Interactions - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Aspects of Anticancer Drug DNA Interactions write by Stephen Neidle. This book was released on 1994-05-03. Molecular Aspects of Anticancer Drug DNA Interactions available in PDF, EPUB and Kindle. This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
Host-Guest Molecular Interactions
Host-Guest Molecular Interactions - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Host-Guest Molecular Interactions write by Derek J. Chadwick. This book was released on 2008-04-30. Host-Guest Molecular Interactions available in PDF, EPUB and Kindle. Composed of contributions from experts in the chemical and biological sciences, it explores host-guest molecular interactions leading to the formation of molecular assemblies containing two or more species. Exciting applications are emerging in this field and it is expected that improved understanding of the interactions in synthetic host molecule complexes will lead to a better understanding of the more complex biological systems. Topics include biomimetic chemistry, preorganization, self-assembly, template-directed synthesis, antibiotic binding to peptides and DNA, interactions between proteins and other molecules.
