Molecular Biology of the Cell - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Biology of the Cell write by . This book was released on 2002. Molecular Biology of the Cell available in PDF, EPUB and Kindle.
Molecular Chaperones and Cell Signalling
Molecular Chaperones and Cell Signalling - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Chaperones and Cell Signalling write by Brian Henderson. This book was released on 2005-07-18. Molecular Chaperones and Cell Signalling available in PDF, EPUB and Kindle. This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?
Heat Shock Proteins in Signaling Pathways
Heat Shock Proteins in Signaling Pathways - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Heat Shock Proteins in Signaling Pathways write by Alexzander A. A. Asea. This book was released on 2019. Heat Shock Proteins in Signaling Pathways available in PDF, EPUB and Kindle. This edited volume offers an insightful overview of contemporary research on signaling pathways. These signaling processes are the comprehensive mechanisms by which all cellular organisms communicate internally and externally with their microenvironment. The volume is focused on heat shock proteins (HSP), which are uniquely involved in a number of critical signaling pathways. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. The knowledge gained from better understanding these mechanisms can help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks write by Peter Csermely. This book was released on 2007-08-09. Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks available in PDF, EPUB and Kindle. This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.
HSF1 and Molecular Chaperones in Biology and Cancer
HSF1 and Molecular Chaperones in Biology and Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook HSF1 and Molecular Chaperones in Biology and Cancer write by Marc Laurence Mendillo. This book was released on 2020-04-15. HSF1 and Molecular Chaperones in Biology and Cancer available in PDF, EPUB and Kindle. Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
