Molecular Mechanisms of Notch Signaling - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Mechanisms of Notch Signaling write by Tilman Borggrefe. This book was released on 2018-07-20. Molecular Mechanisms of Notch Signaling available in PDF, EPUB and Kindle. This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.
Dissecting the Molecular Mechanisms of Notch Signaling
Dissecting the Molecular Mechanisms of Notch Signaling - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Dissecting the Molecular Mechanisms of Notch Signaling write by Jianlin Chu. This book was released on 2004. Dissecting the Molecular Mechanisms of Notch Signaling available in PDF, EPUB and Kindle.
Molecular Mechanisms of Notch Signaling Governing Vascular Smooth Muscle Cell Proliferation
Molecular Mechanisms of Notch Signaling Governing Vascular Smooth Muscle Cell Proliferation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Mechanisms of Notch Signaling Governing Vascular Smooth Muscle Cell Proliferation write by Matthew C. Havrda. This book was released on 2006. Molecular Mechanisms of Notch Signaling Governing Vascular Smooth Muscle Cell Proliferation available in PDF, EPUB and Kindle.
Notch Signaling in Embryology and Cancer
Notch Signaling in Embryology and Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Notch Signaling in Embryology and Cancer write by Jörg Reichrath. This book was released on 2020-02-18. Notch Signaling in Embryology and Cancer available in PDF, EPUB and Kindle. This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
Kidney Development, Disease, Repair and Regeneration
Kidney Development, Disease, Repair and Regeneration - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Kidney Development, Disease, Repair and Regeneration write by Melissa Helen Little. This book was released on 2015-08-06. Kidney Development, Disease, Repair and Regeneration available in PDF, EPUB and Kindle. Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine
