Molecular Mechanisms of Notch Signaling Governing Vascular Smooth Muscle Cell Proliferation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Mechanisms of Notch Signaling Governing Vascular Smooth Muscle Cell Proliferation write by Matthew C. Havrda. This book was released on 2006. Molecular Mechanisms of Notch Signaling Governing Vascular Smooth Muscle Cell Proliferation available in PDF, EPUB and Kindle.
Regulation of Vascular Smooth Muscle Phenotype by Notch Signaling
Regulation of Vascular Smooth Muscle Phenotype by Notch Signaling - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Regulation of Vascular Smooth Muscle Phenotype by Notch Signaling write by Joshua Boucher. This book was released on 2014-12-13. Regulation of Vascular Smooth Muscle Phenotype by Notch Signaling available in PDF, EPUB and Kindle. Vascular smooth muscle cells (VSMC) populate the medial layer of blood vessels and are able to modulate their phenotype in response to environmental cues. Defining the molecular pathways that influence the phenotypic state of VSMC is important for understanding cardiovascular development, vascular repair of injury and numerous vascular pathologies. Notch receptors are expressed throughout the lifecycle of VSMC and contribute to their differentiation and proliferation. Activation of Notch receptors by the ligand Jagged-1 (Jag-1) is believed to be a pro-differentiation signal for VSMC; however, the mechanisms downstream of Notch signaling influencing the phenotypic state of VSMC are not defined. I sought to identify novel gene targets of Jag-1/Notch signaling that promote VSMC differentiation, and to define potential non-overlapping functions of Notch receptors in regulating these genes. I observed decreased proliferation and increased contraction upon activation of Notch signaling by Jag-1 in human aortic VSMC. Using microRNA (miR) arrays, I identified miR-143 and miR-145 (miR-143/145) as enriched by Notch signaling and is required for Notch-induced VSMC differentiation in vitro.
Notch Signaling Guides Vascular Smooth Muscle Cell Function
Notch Signaling Guides Vascular Smooth Muscle Cell Function - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Notch Signaling Guides Vascular Smooth Muscle Cell Function write by Ning Zhao. This book was released on 2014. Notch Signaling Guides Vascular Smooth Muscle Cell Function available in PDF, EPUB and Kindle. Abstract: Proper blood vessel formation and function is crucial for embryogenesis, wound healing, pregnancy and diseases. The interaction of endothelial cells and vascular smooth muscle cells/pericytes is critical for assembling and maintaining blood vessels. Previously, our lab and other groups showed that endothelial cells play an important role in governing vascular smooth muscle cell functions. To further investigate the signaling mechanisms that govern the interaction of vascular cells, we screened for genes and microRNAs whose expression was significantly altered by the endothelial cell-smooth muscle cell interaction.
Endothelial Cell-dependent Notch Signaling Regulates Vascular Smooth Muscle Cell Phenotypes
Endothelial Cell-dependent Notch Signaling Regulates Vascular Smooth Muscle Cell Phenotypes - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Endothelial Cell-dependent Notch Signaling Regulates Vascular Smooth Muscle Cell Phenotypes write by Cho-Hao Lin. This book was released on 2015. Endothelial Cell-dependent Notch Signaling Regulates Vascular Smooth Muscle Cell Phenotypes available in PDF, EPUB and Kindle. Endothelial cell-dependent Notch signaling plays many critical roles in homeostasis and remodeling in the vasculature and serves an important role in the communication between endothelial cells and mural cells, including vascular smooth muscle cells (SMCs), pericytes, and fibroblasts. Our lab previously showed that endothelial cells govern SMC function and promote smooth muscle differentiation. Endothelial cells are able to induce smooth muscle cells into a mature contractile phenotype through cell contact and Notch signaling. Furthermore, Notch signaling has been shown to regulate SMC-specific gene and miR-143/145 expression to govern SMC differentiation. In this study, I demonstrated that endothelial cell-dependent Notch signaling enhances both contractile and synthetic phenotypes in smooth muscle cells, suggesting endothelial cells not only increase the contractile ability of smooth muscle cells, but might also signal to smooth muscle cells to build the basement membrane and form a functional blood vessel. My data indicate that the Notch2 receptor has a unique function in the regulation of SMC proliferation, and the Notch3 receptor has a distinct role in the regulation of synthetic phenotypes in smooth muscle cells.
Molecular Mechanisms of Notch Signaling
Molecular Mechanisms of Notch Signaling - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Mechanisms of Notch Signaling write by Tilman Borggrefe. This book was released on 2018-07-20. Molecular Mechanisms of Notch Signaling available in PDF, EPUB and Kindle. This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.
