EXPLORING MOLECULAR TARGETS TO TREAT NEURODEGENERATIVE DISORDERS. - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook EXPLORING MOLECULAR TARGETS TO TREAT NEURODEGENERATIVE DISORDERS. write by . This book was released on 2024. EXPLORING MOLECULAR TARGETS TO TREAT NEURODEGENERATIVE DISORDERS. available in PDF, EPUB and Kindle.
Protein Misfolding in Neurodegenerative Diseases
Protein Misfolding in Neurodegenerative Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Misfolding in Neurodegenerative Diseases write by Robert D. E. Sewell. This book was released on 2007-12-03. Protein Misfolding in Neurodegenerative Diseases available in PDF, EPUB and Kindle. Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS. A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.
Molecular Targets in Protein Misfolding and Neurodegenerative Disease
Molecular Targets in Protein Misfolding and Neurodegenerative Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Targets in Protein Misfolding and Neurodegenerative Disease write by Pierfausto Seneci. This book was released on 2014-10-07. Molecular Targets in Protein Misfolding and Neurodegenerative Disease available in PDF, EPUB and Kindle. Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a “drug discovery” application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets
Protein folding and misfolding: neurodegenerative diseases
Protein folding and misfolding: neurodegenerative diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein folding and misfolding: neurodegenerative diseases write by Judit Ovádi. This book was released on 2008-12-21. Protein folding and misfolding: neurodegenerative diseases available in PDF, EPUB and Kindle. Offering all the latest in the study of neurodegenerative diseases, this book reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, especially those found in Parkinson’s and Alzheimer’s diseases.
Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases
Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases write by Diana Fernandes Lázaro. This book was released on 2020-02-20. Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases available in PDF, EPUB and Kindle. This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
