Myocardial Biology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Myocardial Biology write by Arnold Schwartz. This book was released on 2013-03-14. Myocardial Biology available in PDF, EPUB and Kindle. It is a pleasure to introduce Volume 5 in the Methods in Pharmacology series. In 1971, Volume 1 of this series was published while I was Head of the Division of Myocardial Biology in the Department of Pharmacology at Baylor College of Medicine in Houston, Texas. I dedicated that first volume to Sir Henry Hallet Dale, who died on July 23, 1968. In the Preface I pointed out that many of the pharmacological advancements that occurred during the last century were direct descendants from the classic paper published in 1910 by Professor Dale and his colleague, Dr. Barger. In this paper, the concept of "specific receptor sites" was introduced by the statement that "the relationship of the recepted mechanism to the base [i. e. , drug base] may well be one of solid solution of adsorption and, therefore, more analogous to that of an enzyme to its substrate . . . . " I also pointed out at that time that the search for drug receptors continues and that fundamental knowledge of the nature of receptors and drug-receptor interaction will eventually lead to a rational approach to drug design. Since 1971, the study of receptors and their interaction with specific chemical substances has continued at an accelerated pace and this is due, in particular, to the introduction of new and exciting methodologies. The death last year of Professor Raymond P. Ahl quist, who pioneered the introduction of specific adrenergic receptors, represents the close of yet another era.
Cellular and Molecular Pathobiology of Cardiovascular Disease
Cellular and Molecular Pathobiology of Cardiovascular Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cellular and Molecular Pathobiology of Cardiovascular Disease write by Monte Willis. This book was released on 2013-12-23. Cellular and Molecular Pathobiology of Cardiovascular Disease available in PDF, EPUB and Kindle. Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. - Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research - Gives concise explanations of key issues and background reading suggestions - Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
How Tobacco Smoke Causes Disease
How Tobacco Smoke Causes Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook How Tobacco Smoke Causes Disease write by United States. Public Health Service. Office of the Surgeon General. This book was released on 2010. How Tobacco Smoke Causes Disease available in PDF, EPUB and Kindle. This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Biophysics of the Failing Heart
Biophysics of the Failing Heart - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biophysics of the Failing Heart write by R. John Solaro. This book was released on 2013-08-13. Biophysics of the Failing Heart available in PDF, EPUB and Kindle. Subjects in the monograph “Biophysics of the Failing Heart” include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.
Heart Failure: A Companion to Braunwald's Heart Disease E-Book
Heart Failure: A Companion to Braunwald's Heart Disease E-Book - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Heart Failure: A Companion to Braunwald's Heart Disease E-Book write by G. Michael Felker. This book was released on 2019-02-06. Heart Failure: A Companion to Braunwald's Heart Disease E-Book available in PDF, EPUB and Kindle. Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald's Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. - Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. - Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. - Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). - Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. - Covers the pathophysiological basis for the development and progression of heart failure. - Serves as a definitive resource to prepare for the ABIM's Heart Failure board exam. - 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).
