Neuro-immune interaction in CNS injury and disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Neuro-immune interaction in CNS injury and disease write by Bo Li. This book was released on 2023-07-24. Neuro-immune interaction in CNS injury and disease available in PDF, EPUB and Kindle.
Neuroimmune Interface in Health and Diseases
Neuroimmune Interface in Health and Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Neuroimmune Interface in Health and Diseases write by Ihssane Zouikr. This book was released on 2017-12-06. Neuroimmune Interface in Health and Diseases available in PDF, EPUB and Kindle. It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
Brain-immune interactions in health and disease
Brain-immune interactions in health and disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Brain-immune interactions in health and disease write by Adam Denes. This book was released on 2015-06-12. Brain-immune interactions in health and disease available in PDF, EPUB and Kindle. Brain-immune interactions are essential to maintain health and their dysfunction contributes to diverse human diseases. Recent data show that haematopoietic processes and immune organs are under central autonomic control. Deficient regulation of inflammatory events contributes to brain diseases, whereas acute or chronic brain injury is linked with the development of systemic inflammatory conditions or immunosuppression. At present, common disorders with high socio-economic burden such as cancer, cardiovascular-, neuroinflammatory- and neurodegenerative diseases, asthma, allergies, autism, psychiatric conditions and sepsis are believed to be influenced, at least in part, by the dysfunction of brain-immune communication. Since the median age of the world's population is increasing rapidly, it is expected that the burden of common non-communicable diseases will further increase, which represents a huge challenge to the health care systems worldwide. Thus, there is an increasing demand to understand and treat complex diseases, many of which are age-related, and this is not possible unless the fine-tuned communication between large systems -such as the nervous and the immune system- is comprehensively understood. Although it is impossible to cover all areas of relevant research in this field, papers in this eBook give some insight to a few important aspects of brain-immune interactions and their contribution to disease. We hope that this collection could stimulate further relevant research and facilitate discussions to support the understanding of the highly complex interactions between the immune system and the brain in health and disease.
Neuro-Immune Connections to Enable Repair in CNS Disorders
Neuro-Immune Connections to Enable Repair in CNS Disorders - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Neuro-Immune Connections to Enable Repair in CNS Disorders write by Tim Vanmierlo. This book was released on 2020-10-28. Neuro-Immune Connections to Enable Repair in CNS Disorders available in PDF, EPUB and Kindle. This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Neuro-Immune Interactions in the Adult Central Nervous System
Neuro-Immune Interactions in the Adult Central Nervous System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Neuro-Immune Interactions in the Adult Central Nervous System write by Oscar González-Pérez. This book was released on 2014-03. Neuro-Immune Interactions in the Adult Central Nervous System available in PDF, EPUB and Kindle. Increasing evidence indicates that inflammatory cells and immunological cytokines can enter into the brain and modulate a number of biological and cognitive functions. Under physiological conditions, only a few immune cells, such as: macrophages, lymphocytes and dendritic cells can cross the blood-brain barrier and gain access to neural tissue. For many years, these findings supported the notion that the brain was an immunologically privileged organ. To date, increasing evidence strongly challenges this conjecture. In fact, neuroinflammation triggers a significant infiltration of immune cells into the cerebral parenchyma. The infiltration of inflammatory cells is accompanied by the release of a number of cytokines that target neurons, astrocytes and microglia. This interaction between the immune system and the central nervous system modulates many cerebral functions, such as: neural remodelling, synaptic plasticity, neurotransmitter releasing, stress-associated response, cognitive and mental disease progression, and others. The book summarises the latest discoveries, from basic to clinical science, regarding the interactions between the immunological mediators and the neural tissue under physiological and pathological conditions. In this book, it is discussed the influence of immune cells and cytokines in neural-regulated systems. Herein, the readers can find comprehensive descriptions in diverse fields, such as: lipids and obesity, neuronal activity, neurotransmission, stress pathogenesis, rheumatologic diseases, spinal cord injuries, regulation of neural stem cells, neural control of reproduction, and others. To ensure that most of readers obtain clear and complete information, all chapters have been written by prominent experts in their respective fields, who explain these topics with a very accessible language. In summary, this book represents a highly-updated compendium about the interactions between the central nervous system and the immune system that could be very useful for undergraduate students, postgraduate students, academic educators or trainers, basic science researchers and clinical physicians.
