Neuroinflammation in Acquired Epilepsy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Neuroinflammation in Acquired Epilepsy write by Jianxiong Jiang. This book was released on 2022-12-01. Neuroinflammation in Acquired Epilepsy available in PDF, EPUB and Kindle.
Inflammation and Epilepsy: New Vistas
Inflammation and Epilepsy: New Vistas - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Inflammation and Epilepsy: New Vistas write by Damir Janigro. This book was released on 2021-05-18. Inflammation and Epilepsy: New Vistas available in PDF, EPUB and Kindle. This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.
The Role of Neuroinflammation in the Development of Acquired Epilepsy Following Acute Intoxication with the Organophosphate Pesticide, Diisopropylfluorophosphate (DFP)
The Role of Neuroinflammation in the Development of Acquired Epilepsy Following Acute Intoxication with the Organophosphate Pesticide, Diisopropylfluorophosphate (DFP) - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Role of Neuroinflammation in the Development of Acquired Epilepsy Following Acute Intoxication with the Organophosphate Pesticide, Diisopropylfluorophosphate (DFP) write by Michelle Ann Guignet. This book was released on 2019. The Role of Neuroinflammation in the Development of Acquired Epilepsy Following Acute Intoxication with the Organophosphate Pesticide, Diisopropylfluorophosphate (DFP) available in PDF, EPUB and Kindle. Organophosphates (OPs) are a group of synthetic compounds that are estimated to be responsible for millions of accidental or intentional human poisonings each year. The canonical mechanism of OP neurotoxicity is inhibition of acetylcholinesterase (AChE); however, multiple lines of evidence suggest that mechanisms in addition to or other than AChE inhibition contribute to the long-term effects associated with acute OP intoxication. It is important to study these pathogenic mechanisms in order to ultimately improve the current standard of care for survivors of acute OP intoxication. The use of preclinical animal models that recapitulate the human condition have been essential for studying the neurologic sequelae following OP poisoning; however, the heterogeneity of responses to different OP compounds suggest that a more thorough characterization of these models is required. In chapter 2, we took advantage of a rodent model of acute intoxication with the OP pesticide, diisopropylfluorophosphate (DFP), to identify that persistent microgliosis, astrogliosis, and oxidative stress responses occur in the same animals with cognitive deficits, affective-like disorders, and acquired epilepsy. Together, these studies highlight potential pathogenic mechanisms that may underlie these behavioral impairments. However, few published studies have reported on the efficacy of therapeutic compounds that target these pathways in reducing long-term behavioral morbidities following acute OP intoxication. Therefore, in chapter 4 we screened twelve pharmacologically distinct compounds for therapeutic potential in reducing OP-induced neurodegeneration and neuroinflammation. We identified compounds with anti-inflammatory properties were the most effective at reducing metrics of microglial activation at 7 days post-DFP, as determined by a self-developed, automated tool (outlined in chapter 3). Furthermore, we determined that daily treatment with minocycline, an FDA-approved tetracycline antibiotic with microglial inhibitory properties, reduced the severity of acquired epilepsy for one month following DFP. These studies suggest that neuroinflammatory mechanisms are likely involved in epileptogenesis following acute OP intoxication and highlight possible therapeutic targets that should be further investigated with the hopes of identifying improved medical countermeasures for survivors of acute OP intoxication.
Homeostatic Control of Brain Function
Homeostatic Control of Brain Function - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Homeostatic Control of Brain Function write by Detlev Boison. This book was released on 2016. Homeostatic Control of Brain Function available in PDF, EPUB and Kindle. Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.
Neuroimaging in Epilepsy
Neuroimaging in Epilepsy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Neuroimaging in Epilepsy write by Harry Chugani, MD. This book was released on 2010-11-23. Neuroimaging in Epilepsy available in PDF, EPUB and Kindle. Perhaps the most important achievements in the field of epileptology in the past two decades have been in the neuroimaging and genetic breakthroughs as applied to patients with epilepsy. Indeed, neuroimaging has become a vital part in the study of epilepsy, affecting broad aspects of the disorder ranging from diagnosis and classification to treatment and prognosis. Neuroimaging in epilepsy encompasses many different approaches that have reached various levels of expertise across epilepsy centers worldwide. This book discusses every imaging modality used to gather information on epilepsy. Each technique is described by world experts and epilepsy centers worldwide.
