OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure write by OECD. This book was released on 2002-02-08. OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure available in PDF, EPUB and Kindle. A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure
Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure write by Organisation for Economic Co-operation and Development. This book was released on 2002. Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure available in PDF, EPUB and Kindle. A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a single sex (normally females) are dosed in a stepwise procedure using the fixed doses of 5, 50, 300 and 2000 mg/kg (exceptionally 5000 mg/kg). The initial dose level is selected on the basis of a sighting study as the dose expected to produce some signs of toxicity without causing severe toxic effects or mortality. Further groups of animals may be dosed at higher or lower fixed doses, depending on the presence or absence of signs of toxicity or mortality. This procedure continues until the dose causing evident toxicity or death is identified, or when no effects are seen at the highest dose or when deaths occur at the lowest dose. The test substance is administered in a single dose by gavage using a stomach tube or a suitable intubation canula. Animals should be fasted prior to dosing. A total of five animals of one sex will normally be used for each dose level investigated. The results of this study include: measurements (weighing at least weekly) and daily detailed observations, as well as gross necropsy. The method provides information on the hazardous properties and allows the substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute Oral toxicity - Acute Toxic Class Method
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute Oral toxicity - Acute Toxic Class Method - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute Oral toxicity - Acute Toxic Class Method write by OECD. This book was released on 2002-02-08. OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute Oral toxicity - Acute Toxic Class Method available in PDF, EPUB and Kindle. This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure write by OECD. This book was released on 2018-06-27. OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure available in PDF, EPUB and Kindle. This method provides information on health hazard likely to arise from short-term exposure to a test chemical by inhalation. It is a principle of the method that only moderately toxic concentrations are used so that ‘evident toxicity’, rather than death/moribundity is used as an endpoint, and ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure write by OECD. This book was released on 2008-10-16. OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure available in PDF, EPUB and Kindle. The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals. It is easiest to ...
