Optical Methods and Instrumentation in Brain Imaging and Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Optical Methods and Instrumentation in Brain Imaging and Therapy write by Steen J. Madsen. This book was released on 2012-11-13. Optical Methods and Instrumentation in Brain Imaging and Therapy available in PDF, EPUB and Kindle. This book provides a comprehensive up-to-date review of optical approaches used in brain imaging and therapy. It covers a variety of imaging approaches including diffuse optical imaging, laser speckle imaging, photoacoustic imaging and optical coherence tomography. A number of laser-based therapeutic techniques are reviewed, including photodynamic therapy, fluorescence guided resection and photothermal therapy. Fundamental principles and instrumentation are discussed for each imaging and therapeutic approach.
Imaging the Brain with Optical Methods
Imaging the Brain with Optical Methods - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Imaging the Brain with Optical Methods write by Anna W. Roe. This book was released on 2009-11-11. Imaging the Brain with Optical Methods available in PDF, EPUB and Kindle. Monitoring brain function with light in vivo has become a reality. The technology 33 of detecting and interpreting patterns of reflected light has reached a degree of 34 maturity that now permits high spatial and temporal resolution visualization at both 35 the systems and cellular levels. There now exist several optical imaging methodolo- 36 gies, based on either hemodynamic changes in nervous tissue or neurally induced 37 light scattering changes, that can be used to measure ongoing activity in the brain. 38 These include the techniques of intrinsic signal optical imaging, near-infrared optical 39 imaging, fast optical imaging based on scattered light, optical imaging with voltage 40 sensitive dyes, and two-photon imaging of hemodynamic signals. The purpose of 41 this volume is to capture some of the latest applications of these methodologies to 42 the study of cerebral cortical function. 43 This volume begins with an overview and history of optical imaging and its use 44 in the study of brain function. Several chapters are devoted to the method of intrin- 45 sic signal optical imaging, a method used to record the minute changes in optical 46 absorption due to hemodynamic changes that accompanies cortical activity. Since the 47 detected hemodynamic changes are highly localized, this method has excellent 48 spatial resolution (50–100 μm ), a resolution sufficient for visualization of fundamen- 49 tal modules of cerebral cortical function.
Neurophotonics and Brain Mapping
Neurophotonics and Brain Mapping - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Neurophotonics and Brain Mapping write by Yu Chen. This book was released on 2017-06-14. Neurophotonics and Brain Mapping available in PDF, EPUB and Kindle. Understanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. Neurophotonics and Brain Mapping covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.
Advanced Optical Methods for Brain Imaging
Advanced Optical Methods for Brain Imaging - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Advanced Optical Methods for Brain Imaging write by Fu-Jen Kao. This book was released on 2018-05-14. Advanced Optical Methods for Brain Imaging available in PDF, EPUB and Kindle. This book highlights the rapidly developing field of advanced optical methods for structural and functional brain imaging. As is known, the brain is the most poorly understood organ of a living body. It is indeed the most complex structure in the known universe and, thus, mapping of the brain has become one of the most exciting frontlines of contemporary research. Starting from the fundamentals of the brain, neurons and synapses, this book presents a streamlined and focused coverage of the core principles, theoretical and experimental approaches, and state-of-the-art applications of most of the currently used imaging methods in brain research. It presents contributions from international leaders on different photonics-based brain imaging modalities and techniques. Included are comprehensive descriptions of many of the technology driven spectacular advances made over the past few years that have allowed novel insights of the structural and functional details of neurons. The book is targeted at researchers, engineers and scientists who are working in the field of brain imaging, neuroscience and connectomics. Although this book is not intended to serve as a textbook, it will appeal to undergraduate students engaged in the specialization of brain imaging.
Miniaturized, Label Free Optical Systems for Imaging Brain Hemodynamics
Miniaturized, Label Free Optical Systems for Imaging Brain Hemodynamics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Miniaturized, Label Free Optical Systems for Imaging Brain Hemodynamics write by Iliya Sigal. This book was released on 2017. Miniaturized, Label Free Optical Systems for Imaging Brain Hemodynamics available in PDF, EPUB and Kindle. This dissertation focuses on instrumentation development for optical monitoring of hemodynamics in rodent brains, which would allow neurophysiologists, conducting pre-clinical research on brain diseases and disorders, to better understand disease onset and progression, and evaluate treatment options. Three specific challenges in applying optical tools to brain imaging were addressed: (1) the limited robustness of optical imaging in the presence of misfocus, (2) the low sensitivity in imaging brain activity under anaesthesia in chronic, longitudinal studies, and (3) the limited penetration depth of optical microscopy in tissue. Two methods were proposed to address misfocus-related imaging artefacts, which enable quantitative optical measurements of blood flow to take place across large fields of view and over long imaging time-frames. A system for blood flow monitoring with extended depth of field was developed, showing improved ability to accurately image flow speeds over large areas in the brain. In addition, a novel measure for misfocus was proposed, enabling robust autofocusing in the presence of measurement noise. A miniaturized, skull-mounted multi-modal optical imaging system was designed for imaging brain blood flow and oxygenation changes in freely-behaving animals. This device constituted the first demonstration of wide-field optical imaging of brain blood flow and oxygenation in a chronic setting, suitable for longitudinal studies of brain disease progression and investigating treatment efficacy. Lastly, a novel endoscopy method was proposed to measure flow speeds of scattering fluids through a single, multi-mode optical fiber. This endoscopy method could enable imaging blood flow speeds in deep brain structures using a minimally-invasive probe that is over 2x smaller than conventional micro-endoscopes used today. Combined, the accomplishments described in this dissertation contributed to making optical measurements of brain hemodynamics applicable to a wider range of imaging assays, and to making optical imaging a more accessible tool for the study of brain vasculature.
