Optimization of Pharmaceutical Processes - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Optimization of Pharmaceutical Processes write by Antonios Fytopoulos. This book was released on 2022-04-06. Optimization of Pharmaceutical Processes available in PDF, EPUB and Kindle. Optimization of Pharmaceutical Processes presents contributions from leading authorities in the fields of optimization and pharmaceutical manufacturing. Formulated within structured frameworks, practical examples and applications are given as guidance to apply optimization techniques to most aspects of pharmaceutical processes from design, to lab and pilot scale, and finally to manufacturing. The increasing demand for better quality, higher yield, more efficient-optimized and green pharmaceutical processes, indicates that optimal conditions for production must be applied to achieve simplicity, lower costs and superior yield. The application of such methods in the pharmaceutical industry is not trivial. Quality of the final product is of major importance to human health and the need for deep knowledge of the process parameters and the optimization of the processes are imperative. The volume, which includes new methods as well as review contributions will benefit a wide readership including engineers in pharmaceuticals, chemical, biological, to name just a few.
Pharmaceutical Drug Product Development and Process Optimization
Pharmaceutical Drug Product Development and Process Optimization - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pharmaceutical Drug Product Development and Process Optimization write by Sarwar Beg. This book was released on 2020-05-01. Pharmaceutical Drug Product Development and Process Optimization available in PDF, EPUB and Kindle. Pharmaceutical manufacturers are constantly facing quality crises of drug products, leading to an escalating number of product recalls and rejects. Due to the involvement of multiple factors, the goal of achieving consistent product quality is always a great challenge for pharmaceutical scientists. This volume addresses this challenge by using the Quality by Design (QbD) concept, which was instituted to focus on the systematic development of drug products with predefined objectives to provide enhanced product and process understanding. This volume presents and discusses the vital precepts underlying the efficient, effective, and cost effective development of pharmaceutical drug products. It focuses on the adoption of systematic quality principles of pharmaceutical development, which is imperative in achieving continuous improvement in end-product quality and also leads to reducing cost, time, and effort, while meeting regulatory requirements. The volume covers the important new advances in the development of solid oral dosage forms, modified release oral dosage forms, parenteral dosage forms, semisolid dosage forms, transdermal drug, delivery systems, inhalational dosage forms, ocular drug delivery systems, nanopharmaceutical products, and nanoparticles for oral delivery.
Optimization of Pharmaceutical R&d Programs and Portfolios
Optimization of Pharmaceutical R&d Programs and Portfolios - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Optimization of Pharmaceutical R&d Programs and Portfolios write by Zoran Antonijevic. This book was released on 2014-10-31. Optimization of Pharmaceutical R&d Programs and Portfolios available in PDF, EPUB and Kindle.
Pharmaceutical Process Modeling, Optimization, and Control
Pharmaceutical Process Modeling, Optimization, and Control - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pharmaceutical Process Modeling, Optimization, and Control write by Ehsan Sheikholeslamzadeh. This book was released on 2013. Pharmaceutical Process Modeling, Optimization, and Control available in PDF, EPUB and Kindle. In this project, the aim was to achieve two important objectives and solve some challenges that the pharmaceutical industry is facing. It will be shown that the NRTL-SAC (Non-random Two Liquid Segment Activity Coefficient) model can best predict the solubility of different pharmaceutical and chemical components in pure and mixed solvents by comparing the results with the well-known model of the UNIFAC. The four parameters that are used in the NRTL-SAC model will be found through nonlinear parameter estimation technique. This project also covers the VLE, LLE, and VLLE phase behaviour calculations using the mentioned models to verify their applicability in industries that use solvents as their main process materials (such as pharmaceutical processes). It will be explained that the NRTL-SAC model is efficient and less complex than the UNIFAC model when dealing with multi-component systems of solvents. The solvent screening process is then modeled using a novel method of modeling and optimization which resulted in a significant change in the objective functions from single to binary solvent combinations. The proposed method shows the efficient selection of single, binary, and ternary solvent systems with the optimal crystallization operating conditions to achieve the desired objectives. However, the change from binary to ternary system of solvents did not have a significant effect on the performance functions. The study on the crystallization process of a polymorphic transformation phenomenon is another part of the project which was modeled and optimized. The novel method of modeling for polymorphic transformation of L-glutamic acid enabled us to develop an optimal control strategy of the system consisting of a variety of process conditions (such as seeded and un-seeded crystallization). The outcome of this part of the project gives a detailed understanding of polymorphic transformation systems with optimal conditions that can be implemented for such processes. Finally some useful experimental work that has been done in the area of nucleation and polymorphic transformation of L-glutamic acid using a powerful spectroscopic probe (Lasentec FBRM) will be explained. The nucleation detection and the change from metastable polymorph to the stable one can be performed using the in-situ FBRM which was used in this project.
Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology
Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology write by Alexandru Mihai Grumezescu. This book was released on 2017-12-11. Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology available in PDF, EPUB and Kindle. Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry
