Oxidative Stress: How has it been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases? - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Oxidative Stress: How has it been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases? write by Claudio Viegas Jr. This book was released on 2021-01-22. Oxidative Stress: How has it been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases? available in PDF, EPUB and Kindle.
Oxidative Stress and Neurodegenerative Disorders
Oxidative Stress and Neurodegenerative Disorders - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Oxidative Stress and Neurodegenerative Disorders write by G. Ali Qureshi. This book was released on 2007-03-22. Oxidative Stress and Neurodegenerative Disorders available in PDF, EPUB and Kindle. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Oxidative Stress and Age-Related Neurodegeneration
Oxidative Stress and Age-Related Neurodegeneration - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Oxidative Stress and Age-Related Neurodegeneration write by Yuan Luo. This book was released on 2005-11-21. Oxidative Stress and Age-Related Neurodegeneration available in PDF, EPUB and Kindle. Oxidative Stress and Age-Related Neurodegeneration brings together researchers from a variety of fields to compare normal aging and disease-related neurodegeneration in terms of susceptibility to and effects of oxidative stress. They address how these effects can be attenuated, and examine whether antioxidants and natural micronutrients, such as those found in Gingko biloba, green tea, blueberries, and grape seed extract, can play a role. The book includes various ways research is getting to the core of neurodegenerative disease, including the use of proteomics, comparisons to related diseases, and examinations at the cellular and molecular levels.
Redox-Signaling in Neurodegenerative Diseases: Biomarkers, Targets, and Therapies
Redox-Signaling in Neurodegenerative Diseases: Biomarkers, Targets, and Therapies - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Redox-Signaling in Neurodegenerative Diseases: Biomarkers, Targets, and Therapies write by Andreia Neves Carvalho. This book was released on 2023-05-16. Redox-Signaling in Neurodegenerative Diseases: Biomarkers, Targets, and Therapies available in PDF, EPUB and Kindle. Redox homeostasis results from the balance between the production of reactive species (e.g. ROS, RNS, etc) and their detoxification by endogenous or exogenous antioxidants. ROS play several important physiological roles, however, their excessive production or impaired detoxification is associated with oxidative stress and cellular injury. Importantly, oxidative damage to vulnerable central nervous system (CNS) cells is a common pathological feature of several neurodegenerative diseases. Antioxidants have been considered as attractive potential therapeutic agents to prevent or halt disease progression but the clinical efficacy of antioxidant treatment strategies is still marginal. Improvement of antioxidant therapy effectiveness might involve adjustment of preclinical to clinical settings and development of new efficient delivery methods and will require a more in-depth knowledge of cellular redox-signaling mechanisms. Promising novel redox-based therapeutic strategies are gaining relevance to combat oxidative stress associated with neurodegenerative diseases. These include boosting the endogenous antioxidant machinery through activation of the antioxidant master regulator Nrf2 (nuclear factor erythroid 2-related factor 2) or modulation of ROS production by NOX (nicotinamide adenine dinucleotide phosphate (NADPH) oxidase) inhibitors. Redox regulation of key cellular functions is currently recognized as an important cellular signaling mechanism and events such as post-translational modifications (e.g. S_glutathionylation, S_nitrosylation, glycosylation, etc) play important roles in redox signal transduction and might be instrumental to uncover pathological mechanisms and identify novel therapeutic targets in neurodegenerative diseases. This Research Topic focuses on redox signaling mechanisms and aims to provide novel insights into the role of redox-signaling, with particular emphasis on redox regulation involving post-translational modifications, in the pathophysiology of neurodegenerative diseases. Moreover, it aims to present an overview of the potential of antioxidants as therapeutics for CNS disorders with a special focus on emerging novel therapeutic redox-based strategies. We are particularly interested in studies: -addressing new redox-based molecular mechanisms contributing to neurodegenerative diseases; -exploring the role of naturally occurring compounds, standard medications, and nutraceuticals with antioxidant properties in modulating redox-signaling pathways and limiting and/or preventing oxidative damage associated with these disorders; -addressing mechanistically the role of post-translational modifications in the pathophysiology of neurodegenerative disorders.
The Role of Oxidative Stress in Neuronal Death
The Role of Oxidative Stress in Neuronal Death - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Role of Oxidative Stress in Neuronal Death write by Irene Ceballos-Picot. This book was released on 2013-06-29. The Role of Oxidative Stress in Neuronal Death available in PDF, EPUB and Kindle. This book examines current knowledge and recent advances in the study of fundamental processes involved in neuronal death, particularly oxidative stress as a causal agent or risk factor. The author presents discussion of oxidative stress in neuronal apoptosis and its role in the neuropathogenesis of age-related neurodegenerative diseases exemplified by Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis.
