PARP Inhibitors for Cancer Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook PARP Inhibitors for Cancer Therapy write by Nicola J. Curtin. This book was released on 2015-06-13. PARP Inhibitors for Cancer Therapy available in PDF, EPUB and Kindle. PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.
Targeting the DNA Damage Response for Cancer Therapy
Targeting the DNA Damage Response for Cancer Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Targeting the DNA Damage Response for Cancer Therapy write by Timothy A. Yap. This book was released on 2023-12-19. Targeting the DNA Damage Response for Cancer Therapy available in PDF, EPUB and Kindle. This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.
HER2-Positive Breast Cancer
HER2-Positive Breast Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook HER2-Positive Breast Cancer write by Sara Hurvitz. This book was released on 2018-07-26. HER2-Positive Breast Cancer available in PDF, EPUB and Kindle. Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today’s available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists.
Poly(ADP-Ribosyl)ation
Poly(ADP-Ribosyl)ation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Poly(ADP-Ribosyl)ation write by Alexander Bürkle. This book was released on 2008-01-11. Poly(ADP-Ribosyl)ation available in PDF, EPUB and Kindle. This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.
Targeting Cell Survival Pathways to Enhance Response to Chemotherapy
Targeting Cell Survival Pathways to Enhance Response to Chemotherapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Targeting Cell Survival Pathways to Enhance Response to Chemotherapy write by . This book was released on 2018-03-28. Targeting Cell Survival Pathways to Enhance Response to Chemotherapy available in PDF, EPUB and Kindle. Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials
