Persister Cells and Infectious Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Persister Cells and Infectious Disease write by Kim Lewis. This book was released on 2019-11-13. Persister Cells and Infectious Disease available in PDF, EPUB and Kindle. This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.
Bacterial Persistence
Bacterial Persistence - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Bacterial Persistence write by Jan Michiels. This book was released on 2015-10-15. Bacterial Persistence available in PDF, EPUB and Kindle. This volume presents a comprehensive collection of methods that have been instrumental to the current understanding of bacterial persisters. Chapters in the book cover topics ranging from general methods for measuring persister levels in Escherichia coli cultures, protocols for the determination of the persister subpopulation in Candida albicans, quantitative measurements of Type I and Type II persisters using ScanLag, to in vitro and in vivo models for the study of the intracellular activity of antibiotics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Persistence: Methods and Protocols brings together the most respected researchers in bacterial persistence whose studies will remain vital to understanding this field for many years to come.
Drug Discovery and Development
Drug Discovery and Development - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Discovery and Development write by Omboon Vallisuta. This book was released on 2015-06-03. Drug Discovery and Development available in PDF, EPUB and Kindle. It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.
Pneumonia Before Antibiotics
Pneumonia Before Antibiotics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pneumonia Before Antibiotics write by Scott H. Podolsky. This book was released on 2006-05-01. Pneumonia Before Antibiotics available in PDF, EPUB and Kindle. “Uses [pneumonia] as a vehicle for examining the evolution of therapeutics in America between the ‘Golden Age of Microbiology’ and the ‘Age of Antibiotics.’”—Isis Focusing largely on the treatment of pneumonia in first half of the century with type-specific serotherapy, clinician-historian Scott H. Podolsky provides insight into the rise and clinical evaluation of therapeutic “specifics,” the contested domains of private practice and public health, and—as the treatment of pneumonia made the transition from serotherapy to chemotherapy and antibiotics—the tempo and mode of therapeutic change itself. Type-specific serotherapy, founded on the tenets of applied immunology, justified by controlled clinical trials, and grounded in a novel public ethos, was deemed revolutionary when it emerged to replace supportive therapeutics. With the advent of the even more revolutionary sulfa drugs and antibiotics, pneumonia ceased to be a public health concern and became instead an illness treated in individual patients by individual physicians. Podolsky describes the new therapeutics and the scientists and practitioners who developed and debated them. He finds that, rather than representing a barren era in anticipation of some unknown transformation to come, the first decades of the twentieth-century shaped the use of, and reliance upon, the therapeutic specific throughout the century and beyond. This intriguing study will interest historians of medicine and science, policymakers, and clinicians alike. “Podolsky’s scholarship is awesome, and his grasp of the philosophical and sociologic context of the issues considered make this an important work.” —New England Journal of Medicine “This thoroughly documented, carefully written book is a landmark analysis . . . It should be read by everyone who is involved in research and therapeutic development.” —JAMA
The Pathogenesis of Infectious Disease
The Pathogenesis of Infectious Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Pathogenesis of Infectious Disease write by Cedric A. Mims. This book was released on 1982. The Pathogenesis of Infectious Disease available in PDF, EPUB and Kindle. The newly revised edition of this work provides an up-to-date description of the mechanisms of infection & disease production in a clear & logical manner. Dealing in an integrated manner with all microorganisms,the factors common to all infectious diseases are set out. Molecular biology, pathology, & immunology are brought together to explain how an infectious agent causes disease, & how the body reacts to it.
