Pharmacokinetic-Pharmacodynamic Modeling and Simulation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pharmacokinetic-Pharmacodynamic Modeling and Simulation write by Peter L. Bonate. This book was released on 2011-07-01. Pharmacokinetic-Pharmacodynamic Modeling and Simulation available in PDF, EPUB and Kindle. This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.
Pharmacokinetic-Pharmacodynamic Modeling and Simulation
Pharmacokinetic-Pharmacodynamic Modeling and Simulation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pharmacokinetic-Pharmacodynamic Modeling and Simulation write by Peter L. Bonate. This book was released on 2006-05-14. Pharmacokinetic-Pharmacodynamic Modeling and Simulation available in PDF, EPUB and Kindle. A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner – each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.
Pharmacokinetic-Pharmacodynamic Modeling and Simulation
Pharmacokinetic-Pharmacodynamic Modeling and Simulation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pharmacokinetic-Pharmacodynamic Modeling and Simulation write by Peter L. Bonate. This book was released on 2005-10-20. Pharmacokinetic-Pharmacodynamic Modeling and Simulation available in PDF, EPUB and Kindle. A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner – each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.
Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition
Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition write by Johan Gabrielsson. This book was released on 2001-11-30. Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition available in PDF, EPUB and Kindle. This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.
Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics
Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics write by Panos Macheras. This book was released on 2006-04-26. Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics available in PDF, EPUB and Kindle. This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
