Pharmacological Investigations on Reactive Oxygen Species in the Cardiovascular System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pharmacological Investigations on Reactive Oxygen Species in the Cardiovascular System write by Carsten Sand. This book was released on 2002. Pharmacological Investigations on Reactive Oxygen Species in the Cardiovascular System available in PDF, EPUB and Kindle.
Reactive Oxygen Species
Reactive Oxygen Species - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Reactive Oxygen Species write by Harald H. H. W. Schmidt. This book was released on 2021-02-23. Reactive Oxygen Species available in PDF, EPUB and Kindle. Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Reactive Oxygen Species and the Cardiovascular System
Reactive Oxygen Species and the Cardiovascular System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Reactive Oxygen Species and the Cardiovascular System write by Augusto C. Montezano. This book was released on 2012. Reactive Oxygen Species and the Cardiovascular System available in PDF, EPUB and Kindle. Reactive oxygen species (ROS) influence various physiological processes including host defense, hormone biosynthesis, and cellular signaling. Increased ROS production (oxidative stress) is implicated in many diseases of the cardiovascular system, including hypertension, atherosclerosis, cardiac failure, stroke, diabetes, and kidney disease. ROS are produced throughout the cardiovascular system, in the kidney and central and peripheral nervous system. A major source for cardiovascular, renal, and neural ROS is a family of non-phagocytic NAD(P)H oxidases, including the prototypic Nox2 homologue-based NAD(P)H oxidase, as well as other NAD(P)H oxidases, such as Nox1 and Nox4. Other possible sources include mitochondrial electron transport enzymes, xanthine oxidase, cyclooxygenase, lipoxygenase, and uncoupled nitric oxide synthase (NOS). NAD(P)H oxidase-derived ROS is important in regulating endothelial function and vascular tone and oxidative stress is implicated in endothelial dysfunction, inflammation, hypertrophy, apoptosis, migration, fibrosis, angiogenesis and rarefaction, important processes involved in vascular remodeling in cardiovascular disease. These findings have evoked considerable interest because of the possibilities that therapies targeted against non-phagocytic NAD(P)H oxidase to decrease ROS generation and/or strategies to increase nitric oxide (NO) availability and antioxidants may be useful in minimizing vascular injury and thereby prevent or regress target organ damage associated with hypertension and other cardiovascular diseases.
Oxygen Radicals in the Pathophysiology of Heart Disease
Oxygen Radicals in the Pathophysiology of Heart Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Oxygen Radicals in the Pathophysiology of Heart Disease write by Pawan K. Singal. This book was released on 2012-12-06. Oxygen Radicals in the Pathophysiology of Heart Disease available in PDF, EPUB and Kindle. Over two centuries ago, oxygen was discovered as "air vital": the component of the earth's atmosphere necessary for life. Less than five years after this discovery, it was found that oxygen was both a life-sustaining and life threatening inhalant as it plays a role in the two extremes of the animal kingdom: life and death. In the subse quent years, we have made major strides in understanding the role of oxygen in maintaining life and volumes of information are now available on this topic. Our knowledge of the contribution of oxygen in cellular dysfunction and cell death which for the most part had lagged behind has begun to catch up. The deleterious ef fects of oxygen radicals and activated oxygen species on a variety of biological systems have now been described. Recently attention has also been focused on the toxic effects of oxygen on the cardiovascular system. The major aim of the present treatise is to offer an integrated view of the pathophysiological aspects of oxygen toxicity in the heart and blood vessels coupled with a review of therapeutic approaches (hopes?) with free radical scavengers and antioxidants. Internationally known expert investigators provide a concise and critical review on the topic of their expertise which also contains data from their own research.
The Influence of Free Radicals and Other Reactive Oxygen Species on Pharmacological Actions in the Cardiovascular System
The Influence of Free Radicals and Other Reactive Oxygen Species on Pharmacological Actions in the Cardiovascular System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Influence of Free Radicals and Other Reactive Oxygen Species on Pharmacological Actions in the Cardiovascular System write by Stephan Leonard Maria Peters. This book was released on 1999. The Influence of Free Radicals and Other Reactive Oxygen Species on Pharmacological Actions in the Cardiovascular System available in PDF, EPUB and Kindle.
