Polarized Light Applications Towards Biomedical Diagnosis and Monitoring - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Polarized Light Applications Towards Biomedical Diagnosis and Monitoring write by Casey William-Munz Pirnstill. This book was released on 2015. Polarized Light Applications Towards Biomedical Diagnosis and Monitoring available in PDF, EPUB and Kindle. Utilization of polarized light for improved specificity and sensitivity in disease diagnosis is occurring more often in fields of sensing, measurement, and medical diagnostics. This dissertation focuses on two distinct areas where polarized light is applied in biomedical sensing/monitoring: The first portion of worked reported in this dissertation focuses on addressing several major obstacles that exist prohibiting the use of polarized light as a means of developing an optical based non-invasive polarimetric glucose sensor to improve the quality of life and disease monitoring for millions of people currently afflicted by diabetes mellitus. In this work there are two key areas, which were focused on that require further technical advances for the technology to be realized as a viable solution. First, in vivo studies performed on New Zealand White (NZW) rabbits using a dual-wavelength polarimeter were conducted to allow for performance validation and modeling for predictive glucose measurements accounting for the time delay associated with blood aqueous humor glucose concentrations in addition to overcoming motion induced birefringence utilizing multiple linear regression analysis. Further, feasibility of non-matched index of refraction eye coupling between the system and corneal surface was evaluated using modeling and verified with in vitro testing validation. The system was initially modeled followed by construction of the non-matched coupling configuration for testing in vitro. The second half of the dissertation focuses on the use of polarized light microscopy designed, built, and tested as a low-cost high quality cellphone based polarimetric imaging system to aid medical health professionals in improved diagnosis of disease in the clinic and in low-resource settings. Malaria remains a major global health burden and new methods for, low-cost, high-sensitivity diagnosis of malaria are needed particularly in remote low-resource areas throughout the world. Here, a cost effective optical cell-phone based transmission polarized light microscope system is presented utilized for imaging the malaria pigment known as hemozoin. Validation testing of the optical resolution required to provide diagnosis similar to commercial polarized imaging systems will be conducted and the optimal design will be utilized in addition to image processing to improve the diagnostic capability. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/155527
The Application of Polarized Light to Biomedical Diagnostics and Monitoring
The Application of Polarized Light to Biomedical Diagnostics and Monitoring - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Application of Polarized Light to Biomedical Diagnostics and Monitoring write by Brent Duane Cameron. This book was released on 2000. The Application of Polarized Light to Biomedical Diagnostics and Monitoring available in PDF, EPUB and Kindle.
Optical Polarization in Biomedical Applications
Optical Polarization in Biomedical Applications - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Optical Polarization in Biomedical Applications write by Valery V. Tuchin. This book was released on 2006-10-12. Optical Polarization in Biomedical Applications available in PDF, EPUB and Kindle. Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.
Polarized Light in Biomedical Imaging and Sensing
Polarized Light in Biomedical Imaging and Sensing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Polarized Light in Biomedical Imaging and Sensing write by Jessica C. Ramella-Roman. This book was released on 2022-11-14. Polarized Light in Biomedical Imaging and Sensing available in PDF, EPUB and Kindle. This book focuses on biomedical applications of polarized light, covering instrumentation and modeling specific to the field. This will be the first book, written by leading researchers in the field, to tackle this important topic. Readers will learn the fundamentals of polarized light transport and how to develop instrumentation for clinical and preclinical studies. They will also become familiar with the latest advancement in data analysis and image processing for a variety of medical applications. The book is dedicated specifically to the biomedical community, including scientists, engineers, and physicians working on the development of instrumentation for clinical and preclinical use. Emphasizes biomedical imaging and sensing; Describes new computational approaches with examples; Provides detailed descriptions of novel instrumentation.
The Use of Polarized Light for Biomedical Applications
The Use of Polarized Light for Biomedical Applications - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Use of Polarized Light for Biomedical Applications write by Justin Shekwoga Baba. This book was released on 2003. The Use of Polarized Light for Biomedical Applications available in PDF, EPUB and Kindle. Polarized light has the ability to increase the specificity of the investigation of biomedical samples and is finding greater utilization in the fields of medical diagnostics, sensing, and measurement. In particular, this dissertation focuses on the application of polarized light to address a major obstacle in the development of an optical based polarimetric non-invasive glucose detector that has the potential to improve the quality of life and prolong the life expectancy of the millions of people afflicted with the disease diabetes mellitus. By achieving the mapping of the relative variations in rabbit corneal birefringence, it is hoped that the understanding of the results contained herein will facilitate the development of techniques to eliminate the effects of changing corneal birefringence on polarimetric glucose measurement through the aqueous humor of the eye. This dissertation also focuses on the application of polarized light to address a major downside of cardiovascular biomechanics research, which is the utilization of toxic chemicals to prepare samples for histological examination. To this end, a polarization microscopy image processing technique is applied to non-stained cardiovascular samples as a means to eliminate, for certain cardiac samples, the necessity for staining using toxic chemicals. The results from this work have the potential to encourage more investigators to join the field of cardiac biomechanics, which studies the remodeling processes responsible for cardiovascular diseases such as myocardial infarct (heart attacks) and congestive heart failure. Cardiovascular disease is epidemic, particularly amongst the population group older than 65 years, and the number of people affected by this disease is expected to increase appreciably as the baby boomer generation transitions into this older, high risk population group. A better understanding of the responsible mechanisms for cardiac tissue remodeling will facilitate the development of better prevention and treatment regimens by improving the early detection and diagnosis of this disease.
