Principles and Methods of Toxicology, Fifth Edition - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Principles and Methods of Toxicology, Fifth Edition write by A. Wallace Hayes. This book was released on 2007-09-25. Principles and Methods of Toxicology, Fifth Edition available in PDF, EPUB and Kindle. Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.
Principles and Methods of Toxicology
Principles and Methods of Toxicology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Principles and Methods of Toxicology write by A. Wallace Hayes. This book was released on 1984-01. Principles and Methods of Toxicology available in PDF, EPUB and Kindle. Hefty and authoritative, the new edition of this reference and text (suitable for graduate level teaching) contains 37 contributed chapters arranged in sections on principles, agents, and methods of toxicology. They provide a state-of-the-art exposition of information related to the task of identifying whether or not a causal relationship exists between specific doses of a chemical and an alleged adverse effect. Current testing procedures, guidelines on data interpretation, and areas of current controversy are covered; new chapters in this edition expand coverage of epidemiology, exposure assessment, and repeat dosing. Editor Hayes is an executive in charge of product integrity at The Gillette Company; contributors are from companies and institutions all over the US. c. Book News Inc.
Principles of Toxicology, Second Edition
Principles of Toxicology, Second Edition - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Principles of Toxicology, Second Edition write by Stine Karen. This book was released on 2006-01-24. Principles of Toxicology, Second Edition available in PDF, EPUB and Kindle. Written by two experienced toxicology lecturers, Principles of Toxicology provides a broad-based yet in-depth introduction to this diverse subject. Comprehensive and easy-to-read, the book covers this broad and interdisciplinary field from the viewpoint of three different functional levels: molecular and cellular; physiological; and ecological and environmental. This revised second edition expands the coverage of the book while keeping the organizational format that made the first edition a bestseller. It also includes a series of brief case studies illustrating the application of toxicological principles to current issues of interest. Each and every chapter has been revised, several have been significantly rewritten, and three are entirely new. This new edition retains the extensive cross-referencing system that links all sections and enhances the integration of material. It also includes an appendix of selected toxicants that describes chemical structure and category of use. These features combine to make finding specific information quick and easy. The highly readable format and uniform, consistent presentation of information will make this the most used reference on your shelf. See what's new in the second edition:
Principles and Methods of Toxicology (student Edition)
Principles and Methods of Toxicology (student Edition) - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Principles and Methods of Toxicology (student Edition) write by A. W. Hayes. This book was released on 1986. Principles and Methods of Toxicology (student Edition) available in PDF, EPUB and Kindle.
Principles of Toxicology Testing, Second Edition
Principles of Toxicology Testing, Second Edition - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Principles of Toxicology Testing, Second Edition write by Frank A Barile. This book was released on 2013-04-02. Principles of Toxicology Testing, Second Edition available in PDF, EPUB and Kindle. Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.
