Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS write by Eric Wickstrom. This book was released on 1991-10-18. Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS available in PDF, EPUB and Kindle. A wide range of new technology involving a direct genetic approach to the treatment of disease using nucleic acid therapeutics is the main focus of this absorbing book. Provides in-depth coverage of the rapid progress of this new technology, from its theoretical stage to its current position at the verge of experimental applications, along with provocative discussions of the therapeutic implications.
Nucleic Acid Therapeutics in Cancer
Nucleic Acid Therapeutics in Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Nucleic Acid Therapeutics in Cancer write by Alan M. Gewirtz. This book was released on 2004-03-25. Nucleic Acid Therapeutics in Cancer available in PDF, EPUB and Kindle. A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.
Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors
Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors write by Eric Wickstrom. This book was released on 2020-08-13. Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors available in PDF, EPUB and Kindle. An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors. Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors furnishes a historical overview of genetic therapy highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications illustrates for new practitioners how each stage of genetic therapy is developed details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.
Antisense Research and Applications
Antisense Research and Applications - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Antisense Research and Applications write by Stanley T. Crooke. This book was released on 1993-05-27. Antisense Research and Applications available in PDF, EPUB and Kindle. Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications. In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs. This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.
Delivery Strategies for Antisense Oligonucleotide Therapeutics
Delivery Strategies for Antisense Oligonucleotide Therapeutics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Delivery Strategies for Antisense Oligonucleotide Therapeutics write by Saghir Akhtar. This book was released on 2017-07-28. Delivery Strategies for Antisense Oligonucleotide Therapeutics available in PDF, EPUB and Kindle. With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.
