Proteases as Targets for Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Proteases as Targets for Therapy write by Klaus, von der Helm. This book was released on 2012-12-06. Proteases as Targets for Therapy available in PDF, EPUB and Kindle. With contributions by numerous experts
Proteases in Health and Disease
Proteases in Health and Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Proteases in Health and Disease write by Sajal Chakraborti. This book was released on 2013-12-04. Proteases in Health and Disease available in PDF, EPUB and Kindle. In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.
Aspartic Acid Proteases as Therapeutic Targets
Aspartic Acid Proteases as Therapeutic Targets - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Aspartic Acid Proteases as Therapeutic Targets write by Arun K. Ghosh. This book was released on 2011-08-04. Aspartic Acid Proteases as Therapeutic Targets available in PDF, EPUB and Kindle. In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.
Viral Proteases and Antiviral Protease Inhibitor Therapy
Viral Proteases and Antiviral Protease Inhibitor Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Viral Proteases and Antiviral Protease Inhibitor Therapy write by Uwe Lendeckel. This book was released on 2009-06-19. Viral Proteases and Antiviral Protease Inhibitor Therapy available in PDF, EPUB and Kindle. The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
Proteases-From Basic Structure to Function to Drug Design as Targeted Therapy
Proteases-From Basic Structure to Function to Drug Design as Targeted Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Proteases-From Basic Structure to Function to Drug Design as Targeted Therapy write by Hang Fai Kwok. This book was released on 2021-12-27. Proteases-From Basic Structure to Function to Drug Design as Targeted Therapy available in PDF, EPUB and Kindle. In the two last decades, proteases have constituted one of the primary and important targets in drug discovery. The U.S. FDA has approved more than 12 protease therapies in the last 10 years, and a number of next-generation or completely new proteases are under clinical development. Protease inhibition strategies are one of the fastest expanding areas in the field of of drugs that show considerable promise. This Special Issue will focus on the recent advances in the discovery and development of protease inhibitors, covering the synthesis of protease inhibitors, the design of new chemical entities acting as inhibitors of special/particular types of proteases, and their mode of actions (Frolova et al. 2020; Slapak et al. 2020; Künnapuu et al. 2021). In addition, the new applications of these interesting compounds/biomolecules and their limitations have been discussed and described (Wang et al. 2020; Bartosová-Sojková et al. 2021).
