Proteasome Inhibitors in Cancer Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Proteasome Inhibitors in Cancer Therapy write by Julian Adams. This book was released on 2004-05-25. Proteasome Inhibitors in Cancer Therapy available in PDF, EPUB and Kindle. A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.
Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy
Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy write by . This book was released on 2018-11-21. Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy available in PDF, EPUB and Kindle. Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials. - Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research - Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms - Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment
The Proteasome — Ubiquitin Protein Degradation Pathway
The Proteasome — Ubiquitin Protein Degradation Pathway - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Proteasome — Ubiquitin Protein Degradation Pathway write by Peter Zwickl. This book was released on 2012-12-06. The Proteasome — Ubiquitin Protein Degradation Pathway available in PDF, EPUB and Kindle. This volume gives an overview of pro tea some-mediated protein degradation and the regulatory role of the ubiquitin system in cellular proteolysis. The first chapter describes the molecular evolution of the proteasome and its associated activators, i. e. , the 20S core, the base and the lid of the 19S cap, and the 11 S regulator. The ensuing chapter gives an overview of the structure and assembly of the 20S proteasome and the regulation of the archaeal proteasome by PAN. The third contribution summarizes our knowledge on the eukaryotic 26S proteasome and its regulation by the 19S regu lator, followed by a chapter devoted to the llS regulator, which elucidates the structural basis for the 11 S-mediated activation of the 20S proteasome. The fifth chapter reviews in detail the role of the proteasome in the immune response. The subsequent chapter of the natural substrates of the gives a comprehensive description proteasome and their recognition by the enzymes of the ubiqui tination machinery. The penultimate chapter rounds up the in formation on intracellular distribution of proteasomes in yeast and mammalian cells, while the last contribution highlights proteasome inhibitors, tools which proved to be very valuable for dissecting the cellular roles of the proteasome and which might turn out to be of pharmacological importance.
Bortezomib in the Treatment of Multiple Myeloma
Bortezomib in the Treatment of Multiple Myeloma - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Bortezomib in the Treatment of Multiple Myeloma write by Irene M. Ghobrial. This book was released on 2010-10-20. Bortezomib in the Treatment of Multiple Myeloma available in PDF, EPUB and Kindle. Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.
HSF1 and Molecular Chaperones in Biology and Cancer
HSF1 and Molecular Chaperones in Biology and Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook HSF1 and Molecular Chaperones in Biology and Cancer write by Marc Laurence Mendillo. This book was released on 2020-04-15. HSF1 and Molecular Chaperones in Biology and Cancer available in PDF, EPUB and Kindle. Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
