Protein-protein Complexes: Analysis, Modeling And Drug Design - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein-protein Complexes: Analysis, Modeling And Drug Design write by Martin Zacharias. This book was released on 2010-05-04. Protein-protein Complexes: Analysis, Modeling And Drug Design available in PDF, EPUB and Kindle. Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions./a
Protein Interactions: Computational Methods, Analysis And Applications
Protein Interactions: Computational Methods, Analysis And Applications - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Interactions: Computational Methods, Analysis And Applications write by M Michael Gromiha. This book was released on 2020-03-05. Protein Interactions: Computational Methods, Analysis And Applications available in PDF, EPUB and Kindle. This book is indexed in Chemical Abstracts ServiceThe interactions of proteins with other molecules are important in many cellular activities. Investigations have been carried out to understand the recognition mechanism, identify the binding sites, analyze the the binding affinity of complexes, and study the influence of mutations on diseases. Protein interactions are also crucial in structure-based drug design.This book covers computational analysis of protein-protein, protein-nucleic acid and protein-ligand interactions and their applications. It provides up-to-date information and the latest developments from experts in the field, using illustrations to explain the key concepts and applications. This volume can serve as a single source on comparative studies of proteins interacting with proteins/DNAs/RNAs/carbohydrates and small molecules.
Drug Design
Drug Design - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Design write by Gerhard Klebe. This book was released on 2013-07-10. Drug Design available in PDF, EPUB and Kindle. Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces.
Protein Interactions as Targets in Drug Discovery
Protein Interactions as Targets in Drug Discovery - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Interactions as Targets in Drug Discovery write by Rossen Donev. This book was released on 2020-05-01. Protein Interactions as Targets in Drug Discovery available in PDF, EPUB and Kindle. Protein Interactions as Targets in Drug Discovery, Volume 121, is dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD), Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis, Aromatic-aromatic interactions in protein-drug and protein-protein interactions, Role of protein-protein interaction in allosteric drug design within the human methyltransferome, and much more. Integrates experimental and computational methods for studying protein interactions and their modulation by potential therapeutics Contains timely chapters written by well-renown authorities in their field Covers information that is well supported by a number of high quality illustrations, figures and tables Targets a very wide audience of specialists, researchers and students
Mathematical Modeling of Protein Complexes
Mathematical Modeling of Protein Complexes - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mathematical Modeling of Protein Complexes write by Tatiana Koshlan. This book was released on 2018-08-24. Mathematical Modeling of Protein Complexes available in PDF, EPUB and Kindle. This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins. The models also take the phosphorylation of amino acid residues into account. At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine.
