Protein Quality Control in Neurodegenerative Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Quality Control in Neurodegenerative Diseases write by Richard I. Morimoto. This book was released on 2012-12-13. Protein Quality Control in Neurodegenerative Diseases available in PDF, EPUB and Kindle. The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
Protein Quality Control in Neurodegenerative Diseases
Protein Quality Control in Neurodegenerative Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Quality Control in Neurodegenerative Diseases write by Richard I. Morimoto. This book was released on 2012-12-12. Protein Quality Control in Neurodegenerative Diseases available in PDF, EPUB and Kindle. The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
Quality Control of Cellular Protein in Neurodegenerative Disorders
Quality Control of Cellular Protein in Neurodegenerative Disorders - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Quality Control of Cellular Protein in Neurodegenerative Disorders write by Uddin, Md. Sahab. This book was released on 2020-02-14. Quality Control of Cellular Protein in Neurodegenerative Disorders available in PDF, EPUB and Kindle. Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.
Molecular Chaperones and Neurodegeneration
Molecular Chaperones and Neurodegeneration - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Chaperones and Neurodegeneration write by Cintia Roodveldt. This book was released on 2017-12-06. Molecular Chaperones and Neurodegeneration available in PDF, EPUB and Kindle. Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.
Fundamentals of Neurodegeneration and Protein Misfolding Disorders
Fundamentals of Neurodegeneration and Protein Misfolding Disorders - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Fundamentals of Neurodegeneration and Protein Misfolding Disorders write by Martin Beckerman. This book was released on 2015. Fundamentals of Neurodegeneration and Protein Misfolding Disorders available in PDF, EPUB and Kindle. This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer's disease and Parkinson's disease to Huntington's disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today's forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
