Protein Surface Recognition by Functional Synthetic Macrocyclic Receptors for Modulation of Protein-protein Interactions - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Surface Recognition by Functional Synthetic Macrocyclic Receptors for Modulation of Protein-protein Interactions write by Lun Kelvin Tsou. This book was released on 2007. Protein Surface Recognition by Functional Synthetic Macrocyclic Receptors for Modulation of Protein-protein Interactions available in PDF, EPUB and Kindle.
Inhibitors of Protein–Protein Interactions
Inhibitors of Protein–Protein Interactions - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Inhibitors of Protein–Protein Interactions write by Ali Tavassoli. This book was released on 2020-12-07. Inhibitors of Protein–Protein Interactions available in PDF, EPUB and Kindle. Protein-protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.
Design and Synthesis of Small-molecule Protein-protein Interaction Antagonists
Design and Synthesis of Small-molecule Protein-protein Interaction Antagonists - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Design and Synthesis of Small-molecule Protein-protein Interaction Antagonists write by Xu Han. This book was released on 2014. Design and Synthesis of Small-molecule Protein-protein Interaction Antagonists available in PDF, EPUB and Kindle. Protein-protein interactions play a crucial role in a wide range of biological processes. Research on the design and synthesis of small molecules to modulate these proteinprotein interactions can lead to new targets and drugs to modulate their function. In chapter one, we discuss the design and synthesis of small molecules to probe a proteinprotein interaction in a voltage-gated Ca2+ channel. Virtual screening identified a compound (BTT-3) that contained a 3,4-dihydro-3,4'-pyrazole core. This compound had modest biological activity when tested in a fluorescence polarization (FP) assay. The synthetic route to BTT-3 consisted of six steps. In addition, analogs of BTT-3 were made for a structure-activity study to establish the importance of a carboxylate moiety. We also synthesized a biotinylated benzophenone photo-affinity probe and linked it to BTT-3 to identify additional protein targets of the compound. In Chapter two, small-molecule antagonists targeting uPA-uPAR protein-protein interaction are presented. A total of 500 commercially-available compounds were previously identified by virtual screening and tested by a FP assay. Three classes of compounds were found with biological activity. The first class of compounds contains pyrrolidone core structures represented by IPR- 1110, the second class has a novel pyrrolo[3,4-c]pyrazole ring system, represented by xv IPR-1283 and the last series had compounds with a 1,2-disubstituted 1,2- dihydropyrrolo[3,4-b]indol-3(4H)-one core structure, represented by IPR-540. Each of these three compounds were synthesized and assessed by FP and ELISA assays. A binding mode of IPR-1110 with uPA was subsequently proposed. Based on this binding mode, another 61 IPR-1110 derivatives were synthesized by us to illustrate the SAR activity. Analogs of the other two series were also synthesized.
Protein Surface Recognition by Synthetic Receptors Based on Macrocylic Scaffolds
Protein Surface Recognition by Synthetic Receptors Based on Macrocylic Scaffolds - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Surface Recognition by Synthetic Receptors Based on Macrocylic Scaffolds write by Rishi K. Jain. This book was released on 2002. Protein Surface Recognition by Synthetic Receptors Based on Macrocylic Scaffolds available in PDF, EPUB and Kindle.
Cytochrome C
Cytochrome C - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cytochrome C write by Robert A. Scott. This book was released on 1996-04-26. Cytochrome C available in PDF, EPUB and Kindle. One of the most heavily researched proteins in existence, cytochrome c has proved irresistible to chemists and biophysicists for decades. This volume serves as a source book to update the vast body of literature compiled on this protein over the last 40 years. Chapters from an internationally renowned group of experts provide extensive coverage of structural studies, spectroscopic properties, thermodynamic properties, electron transfer kinetics and protein modification. "... a valuable addition to the cytochrome literature; I will certainly get a copy for my group." Dr G. R. Moore, University of East Anglia "For any and all students of the science of cytochrome c, this is an indispensable text." SIM News
