Proteostasis and Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Proteostasis and Disease write by Rosa Barrio. This book was released on 2020-04-09. Proteostasis and Disease available in PDF, EPUB and Kindle. This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Protein Homeostasis
Protein Homeostasis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Homeostasis write by Richard I. Morimoto. This book was released on 2012. Protein Homeostasis available in PDF, EPUB and Kindle. Proper folding of proteins is crucial for cell function. Chaperones and enzymes that post-translationally modify newly synthesized proteins help ensure that proteins fold correctly, and the unfolded protein response functions as a homeostatic mechanism that removes misfolded proteins when cells are stressed. This book covers the entire spectrum of proteostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry.
Protein Homeostasis Diseases
Protein Homeostasis Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Homeostasis Diseases write by Angel L. Pey. This book was released on 2020-02-13. Protein Homeostasis Diseases available in PDF, EPUB and Kindle. Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. - Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands - Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease - Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance
Proteostasis and Proteolysis
Proteostasis and Proteolysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Proteostasis and Proteolysis write by Niki Chondrogianni. This book was released on 2022. Proteostasis and Proteolysis available in PDF, EPUB and Kindle. Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. Essential aspects of cell function are proeostasic and relevant for diseases such a cancer, obesity, and aging. Various pharmacological interventions can mitigate the impact of proteostatic breakdown. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system : the ubiquitin-proteasome system and autophagy. These systems and their regulation are affected by endogenous stress and environmental stimuli. Deregulation in proteolysis results in proteostasis failure : protein misfolding and accumulation of damaged and oxidized proteins resulting in neurodegenerative diseases such Alzheimer's, parkinson's, and Huntington's.
Quality Control of Cellular Protein in Neurodegenerative Disorders
Quality Control of Cellular Protein in Neurodegenerative Disorders - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Quality Control of Cellular Protein in Neurodegenerative Disorders write by Uddin, Md. Sahab. This book was released on 2020-02-14. Quality Control of Cellular Protein in Neurodegenerative Disorders available in PDF, EPUB and Kindle. Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.
