Proteostasis and Proteolysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Proteostasis and Proteolysis write by Niki Chondrogianni. This book was released on 2022. Proteostasis and Proteolysis available in PDF, EPUB and Kindle. Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. Essential aspects of cell function are proeostasic and relevant for diseases such a cancer, obesity, and aging. Various pharmacological interventions can mitigate the impact of proteostatic breakdown. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system : the ubiquitin-proteasome system and autophagy. These systems and their regulation are affected by endogenous stress and environmental stimuli. Deregulation in proteolysis results in proteostasis failure : protein misfolding and accumulation of damaged and oxidized proteins resulting in neurodegenerative diseases such Alzheimer's, parkinson's, and Huntington's.
Protein Homeostasis
Protein Homeostasis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Homeostasis write by Richard I. Morimoto. This book was released on 2012. Protein Homeostasis available in PDF, EPUB and Kindle. Proper folding of proteins is crucial for cell function. Chaperones and enzymes that post-translationally modify newly synthesized proteins help ensure that proteins fold correctly, and the unfolded protein response functions as a homeostatic mechanism that removes misfolded proteins when cells are stressed. This book covers the entire spectrum of proteostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry.
Proteostasis and Disease
Proteostasis and Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Proteostasis and Disease write by Rosa Barrio. This book was released on 2020-04-09. Proteostasis and Disease available in PDF, EPUB and Kindle. This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Plant Proteases
Plant Proteases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Plant Proteases write by Mercedes Diaz-Mendoza. This book was released on 2020-01-24. Plant Proteases available in PDF, EPUB and Kindle. Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism. They take part in important pathways like protein turnover by the degradation of misfolded proteins and the ubiquitin-proteasome pathway, and they are responsible for post-translational modifications of proteins by proteolysis at highly specific sites. Proteases are also implicated in a great variety of environmentally controlled processes, including mobilization of storage proteins during seed germination, development of seedlings, senescence, programmed cell death and defense mechanisms against pests and pathogens. However, in spite of their importance, little is known about the functions and mode of actions of specific plant proteases. This Research Topic collects contributions covering diverse aspects of plant proteases research.
Proteostasis and Proteolysis
Proteostasis and Proteolysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Proteostasis and Proteolysis write by Niki Chondrogianni. This book was released on 2021-11-30. Proteostasis and Proteolysis available in PDF, EPUB and Kindle. Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy. Chapter 2 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.
