Psychophysics and Genetics of Zebrafish Visual Behavior - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Psychophysics and Genetics of Zebrafish Visual Behavior write by Michael Brian Orger. This book was released on 2005. Psychophysics and Genetics of Zebrafish Visual Behavior available in PDF, EPUB and Kindle. A central goal of neuroscience is to understand the neural basis of behavior. The zebrafish is a vertebrate model system that allows behavior to be studied using both systems and molecular genetic approaches. Here we present a psychophysical and genetic analysis of optomotor behavior in zebrafish larvae. By applying psychophysical methods developed for primates to zebrafish we have demonstrated than motion detection in zebrafish uses mechanisms that are broadly similar to humans. The larvae are susceptible to visual illusions that indicate that they detect Fourier motion energy in visual scenes. They also respond to non-Fourier motion, an ability that is believed to depend on visual cortex in humans. Different visual behaviors in the fish use different chromatic information. The optomotor response, in particular, is colorblind and pools signals from longer wavelength cones, while excluding shorter wavelength inputs. Motion processing seems to be functionally similar between higher and lower vertebrates despite large differences in neuroanatomy. Using an automated assay, we have conducted a large-scale genetic screen for recessive mutants affecting the optomotor response. Testing these mutants with a battery of behavioral assays allows us to categorize them into motor and visual system mutants, as well as some that are specific to the optomotor response. Many have normal visual system anatomy, but some are missing specific cell-types or have defects in axon target selection.
Behavioral and Neural Genetics of Zebrafish
Behavioral and Neural Genetics of Zebrafish - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Behavioral and Neural Genetics of Zebrafish write by Robert T. Gerlai. This book was released on 2020-04-03. Behavioral and Neural Genetics of Zebrafish available in PDF, EPUB and Kindle. Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
Behavioral Genetic Analysis of the Spatial and Temporal Resolution of Vision in the Zebrafish, Danio Rerio
Behavioral Genetic Analysis of the Spatial and Temporal Resolution of Vision in the Zebrafish, Danio Rerio - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Behavioral Genetic Analysis of the Spatial and Temporal Resolution of Vision in the Zebrafish, Danio Rerio write by Matt Smear. This book was released on 2005. Behavioral Genetic Analysis of the Spatial and Temporal Resolution of Vision in the Zebrafish, Danio Rerio available in PDF, EPUB and Kindle. It is unclear whether the properties of neuronal circuits beyond the retina limit the spatial and temporal resolution of vision. The kinetics of neurotransmission at central synapses should limit an animal's ability to see rapid movements. Accurate retinotopy should be essential for the perception of fine spatial detail. We have tested these predictions using the zebrafish blumenkohl (blu) mutant. Positional cloning revealed that the blu gene encodes vglut2a, a vesicular glutamate transporter expressed by retinal ganglion cells. blu mutants' retinotectal synapses show diminished responses to high frequency electrical stimulation, which should reduce the visibility of fast-moving visual stimuli. Single retinal axons in blu mutants arborize over a larger area in the tectum, blurring the fine detail of the retinotopic map, which should compromise spatial acuity. We tested these hypotheses using assays for optomotor responses and prey capture. Our study provides experimental support for previously untested principles of sensory coding.
The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish
The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish write by Allan V. Kalueff. This book was released on 2017-02-06. The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish available in PDF, EPUB and Kindle. Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book “The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling” explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.
Essential Zebrafish Methods: Genetics and Genomics
Essential Zebrafish Methods: Genetics and Genomics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Essential Zebrafish Methods: Genetics and Genomics write by H. William Detrich III. This book was released on 2009-09-05. Essential Zebrafish Methods: Genetics and Genomics available in PDF, EPUB and Kindle. Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is the prime model for genetic and developmental studies, as well as research in genomics. While genetically distant from humans, nonetheless the vertebrate zebrafish has comparable organs and tissues that make it the model organism for study of vertebrate development.This book, one of two new volumes in the Reliable Lab Solutions series dealing with zebrafish, brings together a robust and up-to-date collection of time-tested methods presented by the world’s leading scientists. Culled from previously published chapters in Methods in Cell Biology and updated by the original authors where relevant, it provides a comprehensive collection of protocols describing the most widely used techniques relevant to the study of zebrafish genetics and genomics. The methods in this volume were hand-selected by the editors, whose goal was to a provide a handy and cost-effective collection of fail-safe methods, tips, and "tricks of the trade" to both experienced researchers and more junior members in the lab. Provides busy researchers a quick reference for time-tested methods and protocols that really work, updated where possible by the original authors Gives pragmatic wisdom to the non-specialist from experts in the field with years of experience with trial and error
