Reactive Oxygen Species and the Cardiovascular System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Reactive Oxygen Species and the Cardiovascular System write by Augusto C. Montezano. This book was released on 2012. Reactive Oxygen Species and the Cardiovascular System available in PDF, EPUB and Kindle. Reactive oxygen species (ROS) influence various physiological processes including host defense, hormone biosynthesis, and cellular signaling. Increased ROS production (oxidative stress) is implicated in many diseases of the cardiovascular system, including hypertension, atherosclerosis, cardiac failure, stroke, diabetes, and kidney disease. ROS are produced throughout the cardiovascular system, in the kidney and central and peripheral nervous system. A major source for cardiovascular, renal, and neural ROS is a family of non-phagocytic NAD(P)H oxidases, including the prototypic Nox2 homologue-based NAD(P)H oxidase, as well as other NAD(P)H oxidases, such as Nox1 and Nox4. Other possible sources include mitochondrial electron transport enzymes, xanthine oxidase, cyclooxygenase, lipoxygenase, and uncoupled nitric oxide synthase (NOS). NAD(P)H oxidase-derived ROS is important in regulating endothelial function and vascular tone and oxidative stress is implicated in endothelial dysfunction, inflammation, hypertrophy, apoptosis, migration, fibrosis, angiogenesis and rarefaction, important processes involved in vascular remodeling in cardiovascular disease. These findings have evoked considerable interest because of the possibilities that therapies targeted against non-phagocytic NAD(P)H oxidase to decrease ROS generation and/or strategies to increase nitric oxide (NO) availability and antioxidants may be useful in minimizing vascular injury and thereby prevent or regress target organ damage associated with hypertension and other cardiovascular diseases.
Redox and Nitrosative Signaling in Cardiovascular System: from Physiological Response to Disease
Redox and Nitrosative Signaling in Cardiovascular System: from Physiological Response to Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Redox and Nitrosative Signaling in Cardiovascular System: from Physiological Response to Disease write by Mariarosaria Santillo. This book was released on 2019-01-22. Redox and Nitrosative Signaling in Cardiovascular System: from Physiological Response to Disease available in PDF, EPUB and Kindle. The role of ROS/RNS signaling in cardiovascular functions and diseases is increasingly emerging in the last decades. The involvement of ROS/RNS in the control of a large number of cardiovascular functions like the regulation of the vascular tone, the control of blood pressure or myocyte excitation-contraction coupling and force development has been broadly investigated and in part clarified. On the other hand, many efforts have been focused in clarifying the redox mechanisms involved in cardiovascular diseases like ischemia/reperfusion injury, diabetes-associated cardiovascular dysfunctions, atherosclerosis or hypertension, just to mention the major ones. However, in most cases the two levels of investigation remain separate and not interlaced, failing in the attempt to provide a unified vision of the pathophysiologic mechanisms of cardiovascular diseases. The major aim of the Research Topic has been to collect original papers and review articles dealing with the issue from basic to translation research point of views. The topic includes contributions that highlight different interesting aspects of cardiovascular biology with an integrated approach useful for the development of new ideas and advancements in the field of redox signaling in the control of normal cardiovascular functions and their disruption in diseases.
Oxidative Stress in Heart Diseases
Oxidative Stress in Heart Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Oxidative Stress in Heart Diseases write by Sajal Chakraborti. This book was released on 2019-11-06. Oxidative Stress in Heart Diseases available in PDF, EPUB and Kindle. This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.
Modulation of Oxidative Stress in Heart Disease
Modulation of Oxidative Stress in Heart Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Modulation of Oxidative Stress in Heart Disease write by Sajal Chakraborti. This book was released on 2019-11-10. Modulation of Oxidative Stress in Heart Disease available in PDF, EPUB and Kindle. This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.
Pharmacological Investigations on Reactive Oxygen Species in the Cardiovascular System
Pharmacological Investigations on Reactive Oxygen Species in the Cardiovascular System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pharmacological Investigations on Reactive Oxygen Species in the Cardiovascular System write by Carsten Sand. This book was released on 2002. Pharmacological Investigations on Reactive Oxygen Species in the Cardiovascular System available in PDF, EPUB and Kindle.
