Recent Advances in Pediatric Cancer Predisposition Syndromes - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Recent Advances in Pediatric Cancer Predisposition Syndromes write by Angela Mastronuzzi. This book was released on 2021-05-03. Recent Advances in Pediatric Cancer Predisposition Syndromes available in PDF, EPUB and Kindle. We would like to acknowledge Dr. Giada Del Baldo and Dr. Mariachiara Lodi from IRCCS Bambino Gesù Children’s Hospital have acted as coordinator and have contributed to the preparation of the proposal for this Research Topic.
Pediatric Cancer Genetics
Pediatric Cancer Genetics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pediatric Cancer Genetics write by Nathaniel H. Robin. This book was released on 2017-08-22. Pediatric Cancer Genetics available in PDF, EPUB and Kindle. Get a quick, expert overview of the many key facets of pediatric cancer genetics with this concise, practical resource by Dr. Nathaniel H. Robin and Meagan Farmer, MS, CGC, MBA. Ideal for pediatric oncologists and all providers who care for children, this easy-to-read reference addresses the remarkable potential of genetic testing as well as the complexities of choosing the correct test, understanding the results, and counseling the family. Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counselors. Highlights examples of syndromes that present in childhood and increase susceptibility to cancer. Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer. Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples. Consolidates today’s available information and guidance in this timely area into one convenient resource.
Exploring the Use of Decision Support Tools to Evaluate Cancer Predisposition Syndromes in Pediatrics
Exploring the Use of Decision Support Tools to Evaluate Cancer Predisposition Syndromes in Pediatrics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Exploring the Use of Decision Support Tools to Evaluate Cancer Predisposition Syndromes in Pediatrics write by Cristal Namuhoranye. This book was released on 2022. Exploring the Use of Decision Support Tools to Evaluate Cancer Predisposition Syndromes in Pediatrics available in PDF, EPUB and Kindle. "Background: Cancer predispositions syndromes (CPSs) are genetic conditions that increase the likelihood of developing cancer throughout a patient's lifetime. For pediatric cancer patients, CPSs are particularly relevant, as this population is less likely to develop malignancies from environmental exposures or other cancer-associated lifestyle factors. In fact, recent advances in the field of cancer genetics have elucidated the importance of recognizing the multitude of CPSs that may impact treatment plans, cancer surveillance and/or preventative measures for pediatric patients and their families. As a result, the last 20 years have seen a rise in decision-support tools (DSTs) that aim to guide health care practitioners in their evaluations of underlying CPSs. Currently, the scope of DSTs used to evaluate pediatric CPSs has yet to be described and their clinical application across Canadian institutions is not well understood. Objectives: The primary goal of this thesis is to identify, describe and categorize the features of DSTs developed for the pediatric oncology population. The second goal is to establish how these tools are being adopted in clinical settings, by assessing their utility to pediatric hematologist- oncologists (PHOs) across Canadian tertiary-care hospitals. Methods: An initial scoping review was performed to identify the pediatric-adapted DSTs that utilize the patient's clinical features to determine whether they are likely to have an underlying CPS. Using the Joanna Briggs Institute scoping review methodology, a systematic search strategy was developed and customized for MEDLINE and EMBASE databases. Subsequently, the tools identified in the scoping review informed a survey electronically distributed to PHOs across the 16 largest pediatric oncology departments in Canada. Their awareness and attitude towards DSTs were solicited on an anonymous basis. Results: Fourteen DSTs were identified, of which (8/14) (57%) have been internally or externally validated for clinical use. Half of the DSTs were specific to one CPS (7/14); the majority were published in a paper-based format (11/14); developed to input the patient's tumour type (14/14), family history of cancer (12/14), non-malignant physical findings (8/14); and developed to output their recommendation in a dichotomous form (10/14).With the online survey, a total of 36 responses from PHOs were recorded: 18/36 (50%) of the respondents had previously used a DST, while 15/36 (41.7%) had not, and 3 were uncertain. Users of DSTs did not solely rely on the tool's recommendation but used it as part of their decision-making process. Non-DST users were often unaware of the existence of these tools or how to gain access to them. Both DST users and non-users stated that a tool's ease-of-use, its accessibility, and its promotion by their academic institution constitute the most important features for a tool's adoption into their clinical practice.Conclusion: Fourteen pediatric CPS DSTs were identified through a scoping review; these were developed with a wide range of input/output parameters, formats, and types of CPSs and malignancies being evaluated. Despite the need for additional resources, the use of DSTs in clinical settings is not prominent, as half of the surveyed physicians have not previously used a DST and most tools remain unknown to them. With further development of DSTs' ease-of-use, accessibility, and evidence of their clinical benefit, adoption of DSTs in clinical practices across the country may become more systematic and lead to the increased recognition of CPSs in pediatric patients"--
Primary Immunodeficiency Diseases
Primary Immunodeficiency Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Primary Immunodeficiency Diseases write by Hans D. Ochs. This book was released on 2007. Primary Immunodeficiency Diseases available in PDF, EPUB and Kindle. The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
Childhood Cancer and Functional Impacts Across the Care Continuum
Childhood Cancer and Functional Impacts Across the Care Continuum - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Childhood Cancer and Functional Impacts Across the Care Continuum write by National Academies of Sciences Engineering and Medicine. This book was released on 2021-09-09. Childhood Cancer and Functional Impacts Across the Care Continuum available in PDF, EPUB and Kindle. Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.
