Redox Signaling and Biomarkers in Ageing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Redox Signaling and Biomarkers in Ageing write by Ufuk Çakatay. This book was released on 2021-12-02. Redox Signaling and Biomarkers in Ageing available in PDF, EPUB and Kindle. This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.
Redox Signaling and Regulation in Biology and Medicine
Redox Signaling and Regulation in Biology and Medicine - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Redox Signaling and Regulation in Biology and Medicine write by Claus Jacob. This book was released on 2009-05-06. Redox Signaling and Regulation in Biology and Medicine available in PDF, EPUB and Kindle. This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.
Cellular Implications Of Redox Signaling
Cellular Implications Of Redox Signaling - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cellular Implications Of Redox Signaling write by Avihai Danon. This book was released on 2003-07-30. Cellular Implications Of Redox Signaling available in PDF, EPUB and Kindle. Redox regulation, like phosphorylation, is a covalent regulatory system that controls many of the normal cellular functions of all living cells and organisms. In addition, it controls how cells respond to stress involving oxidants and free radicals, which underlie many degenerative diseases. This area is undergoing a transition from general knowledge to specific description of the components and mechanisms involved.This invaluable book provides a timely basic description of a field whose relevance to cell biology and degenerative diseases is of the utmost importance. It describes the state of the art, lays the foundations for understanding the reactions involved, and presents the prospects for future developments. It can serve as a basic text for any undergraduate or graduate course that deals with redox regulation, oxidative stress and free radicals under normal and pathological conditions in bacterial, plant and animal cells.
Oxidative Stress and Redox Regulation
Oxidative Stress and Redox Regulation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Oxidative Stress and Redox Regulation write by Ursula Jakob. This book was released on 2013-03-15. Oxidative Stress and Redox Regulation available in PDF, EPUB and Kindle. Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.
Redox Homeostasis in Plants
Redox Homeostasis in Plants - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Redox Homeostasis in Plants write by Sanjib Kumar Panda. This book was released on 2019-04-23. Redox Homeostasis in Plants available in PDF, EPUB and Kindle. This book summarizes the latest research results on the role of reactive oxygen species (ROS) in plants, particularly in many abiotic stresses, and their regulation. Redox homeostasis refers to maintaining a balance of oxidised and reduced state of biomolecules in a biological system for all-round sustenance. In a living system, redox reactions contribute to the generation of reactive oxygen species (ROS), which act as signalling molecules for developmental as well as stress-response processes in plants. It is presumed that, being sessile and an aerobe requiring oxygen for mitochondrial energy production, as well as producing oxygen during photosynthesis, the redox homeostasis process is more complex and regulated in plants than in animals. Any imbalance in the homeostasis is mainly compensated for by the production of various ROS molecules, which, though they can cause severe oxidative damage in excess, can also ideally act as signalling molecules.
