Kidney Development, Disease, Repair and Regeneration - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Kidney Development, Disease, Repair and Regeneration write by Melissa Helen Little. This book was released on 2015-08-06. Kidney Development, Disease, Repair and Regeneration available in PDF, EPUB and Kindle. Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine
Regenerative Nephrology
Regenerative Nephrology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Regenerative Nephrology write by Michael S. Goligorsky. This book was released on 2010-11-26. Regenerative Nephrology available in PDF, EPUB and Kindle. Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney
Kidney Transplantation, Bioengineering, and Regeneration
Kidney Transplantation, Bioengineering, and Regeneration - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Kidney Transplantation, Bioengineering, and Regeneration write by Giuseppe Orlando. This book was released on 2017-06-08. Kidney Transplantation, Bioengineering, and Regeneration available in PDF, EPUB and Kindle. Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function
Regenerative Nephrology
Regenerative Nephrology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Regenerative Nephrology write by Michael S. Goligorsky. This book was released on 2021-06-12. Regenerative Nephrology available in PDF, EPUB and Kindle. Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition. A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes A new section on tissue engineering of the kidney of interest to nephrologists and urologists An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues
Renal Repair and Regeneration
Renal Repair and Regeneration - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Renal Repair and Regeneration write by Carlos El Hader. This book was released on 2006. Renal Repair and Regeneration available in PDF, EPUB and Kindle. "The process of kidney regeneration recapitulates many aspect of development; it involves cell migration, proliferation and differentiation. Our previous studies point to the involvement of HCaRG "Hypertension-related calcium-regulated gene" in two major processes contributing to kidney repair, i.e. control of cell proliferation and differentiation. We extended our studies on the cellular function of HCaRG by comparing cell migration of two kidney cell lines. HCaRG expressing HEK293 cells, which undergo lower proliferation, migrated faster than control cells and presented greater adhesiveness to the extracellular matrix. Faster migration was also observed for the MDKC-C7 cells, after stably transfecting them with HCaRG cDNA. Screening of a human kidney cDNA library with HCaRG as bait revealed its interaction with several ionic transporters, among them Na+,K+,2Cl- cotransporter (NKCC) and Na,K-ATPase (NK pump). HCaRG overexpression induced major morphological changes of HEK293 cells including the formation of lamellipodia. An interaction and a co-localization were further found between HCaRG and actin at the leading edge of migrating cells. Increased activities of the NK pump and NKCC were observed in MDCK-C7 cells expressing HCaRG. These cells displayed higher content of intracellular Na+, water, and total proteins. Ouabain and bumetanide dose-dependently suppressed cells migration with keeping a higher migratory potential for the HCaRG-expressing HEK293 cells. Expression microarrays of HCaRG clones cells resulted in a profile of differential regulation of molecules involved in cell proliferation, differentiation and migration as well as molecules involved in morphogenesis and cytoskeleton organization. Among the quantitatively most up-regulated genes was the transforming growth factor-alpha (TGF-a) which has been associated with normal renal development and recovery. HCaRG-expressing cells exhibited augmented synthesis and release of activated TGF-a and" --
