Response Surface Methods for Assessing Synergistic Effects of Three Or More Drugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Response Surface Methods for Assessing Synergistic Effects of Three Or More Drugs write by John Oleynick. This book was released on 2013. Response Surface Methods for Assessing Synergistic Effects of Three Or More Drugs available in PDF, EPUB and Kindle. Drug synergy occurs when two or more drugs are used in a combination therapy, and the total effect of the drugs is more than would be expected based on their individual effects. Although numerous methods exist for evaluating synergy between two drugs, few have been developed for three or more drugs, and most of them have some significant drawbacks. This dissertation extends a number of two-drug synergy methods to accommodate three or more drugs. First, the method of Plummer and Short [27] is extended to three or more drugs, which is an appropriate method for cases where only global synergy may be present. Next, the parametric method of Kong and Lee [19] is extended, which is appropriate for cases where local synergy may be present. Finally, the semiparametric method of Kong and Lee [20] is extended to three or more drugs, which is an appropriate method for cases where either local synergy may be present or where the model assumptions of the extended Plummer and Short method and the extended Kong and Lee methods are not met. For each method, synergy models are presented for the case of n drugs; the models are then implemented and evaluated using simulated data for the case of three drugs, and their goodness of fit is evaluated using simulations. When more than two drugs are used in a combination, there is an additional complexity not present in 2-drug synergy: determining whether any detected synergy is between all n drugs or only a subset of the drugs. All of the new methods presented in this dissertation are able to make that distinction.
Statistical Methods in Drug Combination Studies
Statistical Methods in Drug Combination Studies - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Statistical Methods in Drug Combination Studies write by Wei Zhao. This book was released on 2014-12-19. Statistical Methods in Drug Combination Studies available in PDF, EPUB and Kindle. The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical methodologies. The theoretical development, coupled with advances in statistical computing, makes it possible to apply these emerging statistical methods in in vitro and in vivo drug combination assessments. Howeve
Drug Synergism and Dose-Effect Data Analysis
Drug Synergism and Dose-Effect Data Analysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Synergism and Dose-Effect Data Analysis write by Ronald J. Tallarida. This book was released on 2000-07-21. Drug Synergism and Dose-Effect Data Analysis available in PDF, EPUB and Kindle. Not since this author's bestselling Manual of Pharmacologic Calculation has there been an available reference for drug data analysis. Incorporating the most relevant parts of that work, Drug Synergism and Dose-Effect Data Analysis focuses on drug combinations and all the quantitative analyses needed to analyze drug combination dose-effect data and to design experiments with two or more compounds. The book contains the statistical methods, the theory, and the computation algorithms needed to analyze single and combination drug data. Numerous examples accompany a presentation that illustrates the calculations and experimental design considerations for modern drug analysis.
Journal of the National Cancer Institute
Journal of the National Cancer Institute - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Journal of the National Cancer Institute write by . This book was released on 2011. Journal of the National Cancer Institute available in PDF, EPUB and Kindle.
Antimicrobial Drug Resistance
Antimicrobial Drug Resistance - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Antimicrobial Drug Resistance write by Douglas L. Mayers. This book was released on 2017-06-19. Antimicrobial Drug Resistance available in PDF, EPUB and Kindle. The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.
