Review of EPA's Integrated Risk Information System (IRIS) Process - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Review of EPA's Integrated Risk Information System (IRIS) Process write by National Research Council. This book was released on 2014-06-25. Review of EPA's Integrated Risk Information System (IRIS) Process available in PDF, EPUB and Kindle. The Integrated Risk Information System (IRIS) is a program within the US Environmental Protection Agency (EPA) that is responsible for developing toxicologic assessments of environmental contaminants. An IRIS assessment contains hazard identifications and dose-response assessments of various chemicals related to cancer and noncancer outcomes. Although the program was created to increase consistency among toxicologic assessments within the agency, federal, state, and international agencies and other organizations have come to rely on IRIS assessments for setting regulatory standards, establishing exposure guidelines, and estimating risks to exposed populations. Over the last decade, the National Research Council (NRC) has been asked to review some of the more complex and challenging IRIS assessments, including those of formaldehyde, dioxin, and tetrachloroethylene. In 2011, an NRC committee released its review of the IRIS formaldehyde assessment. Like other NRC committees that had reviewed IRIS assessments, the formaldehyde committee identified deficiencies in the specific assessment and more broadly in some of EPA's general approaches and specific methods. Although the committee focused on evaluating the IRIS formaldehyde assessment, it provided suggestions for improving the IRIS process and a roadmap for its revision in case EPA decided to move forward with changes to the process. Congress directed EPA to implement the report's recommendations and then asked the National Research Council to review the changes that EPA was making (or proposing to make) in response to the recommendations. Review of EPA's Integrated Risk Information System (IRIS) Process provides an overview of some general issues associated with IRIS assessments. This report then addresses evidence identification and evaluation for IRIS assessments and discusses evidence integration for hazard evaluation and methods for calculating reference values and unit risks. The report makes recommendations and considerations for future directions. Overall, Review of EPA's Integrated Risk Information System Process finds that substantial improvements in the IRIS process have been made, and it is clear that EPA has embraced and is acting on the recommendations in the NRC formaldehyde report. The recommendations of this report should be seen as building on the progress that EPA has already made.
Review of EPA's Integrated Risk Information System (IRIS) Process
Review of EPA's Integrated Risk Information System (IRIS) Process - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Review of EPA's Integrated Risk Information System (IRIS) Process write by . This book was released on 2014. Review of EPA's Integrated Risk Information System (IRIS) Process available in PDF, EPUB and Kindle.
Progress Toward Transforming the Integrated Risk Information System (IRIS) Program
Progress Toward Transforming the Integrated Risk Information System (IRIS) Program - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Progress Toward Transforming the Integrated Risk Information System (IRIS) Program write by National Academies of Sciences, Engineering, and Medicine. This book was released on 2018-04-11. Progress Toward Transforming the Integrated Risk Information System (IRIS) Program available in PDF, EPUB and Kindle. Over the past several years, the US Environmental Protection Agency (EPA) has been transforming the procedures of its Integrated Risk Information System (IRIS), a program that produces hazard and doseâ€'response assessments of environmental chemicals and derives toxicity values that can be used to estimate risks posed by exposures to them. The transformation was initiated after suggestions for program reforms were provided in a 2011 report from the National Academies of Sciences, Engineering, and Medicine that reviewed a draft IRIS assessment of formaldehyde. In 2014, the National Academies released a report that reviewed the IRIS program and evaluated the changes implemented in it since the 2011 report. Since 2014, new leadership of EPA's National Center for Environmental Assessment (NCEA) and IRIS program has instituted even more substantive changes in the IRIS program in response to the recommendations in the 2014 report. Progress Toward Transforming the Integrated Risk Information System Program: A 2018 Evaluation reviews the EPA's progress toward addressing the past recommendations from the National Academies.
Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde
Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde write by National Research Council. This book was released on 2011-05-31. Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde available in PDF, EPUB and Kindle. Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.
Progress Toward Transforming the Integrated Risk Information System (IRIS) Program
Progress Toward Transforming the Integrated Risk Information System (IRIS) Program - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Progress Toward Transforming the Integrated Risk Information System (IRIS) Program write by National Academies of Sciences, Engineering, and Medicine (U.S.). Committee to Review Advances Made to the IRIS Process. This book was released on 2018. Progress Toward Transforming the Integrated Risk Information System (IRIS) Program available in PDF, EPUB and Kindle. "Over the past several years, the US Environmental Protection Agency (EPA) has been transforming the procedures of its Integrated Risk Information System (IRIS), a program that produces hazard and dose‒response assessments of environmental chemicals and derives toxicity values that can be used to estimate risks posed by exposures to them. The transformation was initiated after suggestions for program reforms were provided in a 2011 report from the National Academies of Sciences, Engineering, and Medicine that reviewed a draft IRIS assessment of formaldehyde. In 2014, the National Academies released a report that reviewed the IRIS program and evaluated the changes implemented in it since the 2011 report. Since 2014, new leadership of EPA’s National Center for Environmental Assessment (NCEA) and IRIS program has instituted even more substantive changes in the IRIS program in response to the recommendations in the 2014 report. Progress Toward Transforming the Integrated Risk Information System Program: A 2018 Evaluation reviews the EPA’s progress toward addressing the past recommendations from the National Academies" -- Publisher's description
