Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing write by Charles E. Samuel. This book was released on 2011-11-06. Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing available in PDF, EPUB and Kindle. “The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.”
RNA and DNA Editing
RNA and DNA Editing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNA and DNA Editing write by Harold C. Smith. This book was released on 2008-04-25. RNA and DNA Editing available in PDF, EPUB and Kindle. RNA and DNA Editing assembles a team of leading experts who present the latest discoveries in the field alongside the latest models and methodology. In addition, the authors set forth the many open questions and suggest routes for further investigation. Overall, the book serves as a practical guide for professionals in the field who need to understand the interrelationship of RNA and DNA editing with other chemical and biological processes.
Human Genome Editing
Human Genome Editing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Human Genome Editing write by National Academies of Sciences, Engineering, and Medicine. This book was released on 2017-08-13. Human Genome Editing available in PDF, EPUB and Kindle. Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.
RNA and DNA Editing
RNA and DNA Editing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNA and DNA Editing write by Ruslan Aphasizhev. This book was released on 2011-08-24. RNA and DNA Editing available in PDF, EPUB and Kindle. The recent expansion in diversity of RNA and DNA editing types has stimulated the development of many unique genetic, molecular, biochemical, and computational approaches to biological issues. In RNA and DNA Editing: Methods and Protocols, leading experts in the field introduce methods developed over the last few years to study editing substrates, mechanisms of specificity, and functions of RNA and DNA editing enzymes and complexes. Sections of the book are dedicated to state-of-the art techniques which enable investigation of uracil insertion/deletion RNA editing in mitochondrion of Trypanosoma brucei, adenosine to inosine RNA editing, cytidine to uracil RNA and DNA editing, as well as tRNA editing and RNA modifications. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNA and DNA Editing: Methods and Protocols seeks to inspire the further development of these vital and powerful techniques.
Heritable Human Genome Editing
Heritable Human Genome Editing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Heritable Human Genome Editing write by The Royal Society. This book was released on 2021-01-16. Heritable Human Genome Editing available in PDF, EPUB and Kindle. Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
