RNA Interference from Biology to Therapeutics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNA Interference from Biology to Therapeutics write by Kenneth A. Howard. This book was released on 2012-10-19. RNA Interference from Biology to Therapeutics available in PDF, EPUB and Kindle. The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.
RNAi Technology
RNAi Technology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNAi Technology write by R. K. Gaur. This book was released on 2016-04-19. RNAi Technology available in PDF, EPUB and Kindle. RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA
Therapeutic Applications of RNAi
Therapeutic Applications of RNAi - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Therapeutic Applications of RNAi write by John F. Reidhaar-Olson. This book was released on 2009-07-09. Therapeutic Applications of RNAi available in PDF, EPUB and Kindle. The phenomenon of RNA interference has rapidly moved from groundbreaking scientific discovery to promising therapeutic approach. However, even as RNAi-based drugs enter the clinic, significant challenges remain, particulary in the area of delivery. Therapeutic Applications of RNAi provides detailed protocols in key areas of current focus, including testing of delivery vehicles, identification of appropriate model systems, and evaluation of the effects of RNAi in vivo. Produced by a team of internationally renowned authors, the volume describes the therapeutic applications of RNAi and potential pitfalls in oncology, viral infections and CNS disease, using a variety of delivery methods, including liposomes, peptide-based nanoparticles, polycationic polymers, and viral vehicles. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Therapeutic Applications of RNAi is an ideal guide for scientists attempting to solve the numerous challenges in this field and revolutionize the treatment of disease.
Advanced Delivery and Therapeutic Applications of RNAi
Advanced Delivery and Therapeutic Applications of RNAi - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Advanced Delivery and Therapeutic Applications of RNAi write by Kun Cheng. This book was released on 2013-04-19. Advanced Delivery and Therapeutic Applications of RNAi available in PDF, EPUB and Kindle. Commonly used by researchers to develop technologies for modifying and studying genetic process, RNA interference (RNAi) has many potential uses in medicine, biotechnology, and functional genomics. This book covers all essential aspects involved in the development of RNAi therapeutics, providing detailed guidance on the challenges and opportunities of bringing RNAi technologies from bench to clinic. It explores the design and mechanism of RNAi molecules, delivery strategies, and therapeutic applications in various diseases. Preclinical, regulatory, market, and intellectual aspects of RNAi technologies are also covered.
RNAi
RNAi - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNAi write by Gregory J. Hannon. This book was released on 2003. RNAi available in PDF, EPUB and Kindle. In the past three years, the use of double-stranded RNA to silence gene activity has become widely and rapidly adopted. RNA interference is highly specific and remarkably potent, and it acts on cells and tissues far removed from the site of introduction. The principles behind RNAi are just being uncovered, but this laboratory technique has been applied effectively in a wide variety of animal and plant species. Variations on RNAi are revolutionizing many approaches to experimental biology, complementing traditional genetic technologies with a quicker and less expensive way of mimicking the effects of mutations both in cell cultures and in living animals. Recent advances in the use of RNAi to engineer heritable silencing in mammals, to alter stem cells for organ reconstitution, and to alter the course of disease in model systems indicate that RNAi may have a future in disease therapy. Written by pioneers in this new field and edited by Gregory Hannon, one of its leading figures, RNAi: A Guide to Gene Silencing presents the principles of RNAi and reliable protocols for its laboratory use in Caenorhabditis elegans, Drosophila, plants, avian embryos, mammalian cells, mouse oocytes, and more. This important and unique book is an essential laboratory resource for scientists studying gene regulation and for all experimental biologists interested in the emerging practical applications of RNAi.
