RNA Worlds - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNA Worlds write by Thomas Cech. This book was released on 2019. RNA Worlds available in PDF, EPUB and Kindle.
Bidirectional Gene Promoters
Bidirectional Gene Promoters - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Bidirectional Gene Promoters write by Fumiaki Uchiumi. This book was released on 2022-11-25. Bidirectional Gene Promoters available in PDF, EPUB and Kindle. Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5'-upstream regions of gene pairs are referred to as bi-directional promoters and are thought to have a key role in biological regulatory mechanisms. For example, tumor suppressor protein-encoding TP53 and BRCA1 genes are head-head bound with WRAP53 and NBR2, respectively. DNA-repair factor-encoding ATM and PRKDC (DNA-PKcs) genes have bidirectional partner NPAT and MCM4, respectively. Surveillance of the human DNA database has revealed that the numbers of DNA repair/mitochondrial function/immune response-associated genes are bound with other genes that are transcribed to opposite direction. The observations may encourage us to investigate in the molecular mechanisms how DNA repair/mitochondrial function/immune response-associated genes are regulated by bidirectional promoters. Not only protein-coding genes, but also quite a few ncRNAs, which play important roles in various cellular events, are transcribed under the regulation of the bidirectional promoters. More importantly, we know that dysregulation in the promoter activity and transcription initiation of genes might cause human diseases. - Provides an overview of the process of transcription - Explains why there so many bidirectional promoters present in human genomes - Covers how the diverse biological functions of (non-coding RNAs) ncRNAs are controlled
RNA Worlds: New Tools for Deep Exploration
RNA Worlds: New Tools for Deep Exploration - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNA Worlds: New Tools for Deep Exploration write by Thomas R. Cech. This book was released on 2018-12-31. RNA Worlds: New Tools for Deep Exploration available in PDF, EPUB and Kindle. "A Subject Collection from Cold Spring Harbor Perspectives in Biology."
Ribosome Biogenesis
Ribosome Biogenesis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Ribosome Biogenesis write by Karl-Dieter Entian. This book was released on 2022-07-07. Ribosome Biogenesis available in PDF, EPUB and Kindle. This Open Access volume provides comprehensive reviews and describes the latest techniques to study eukaryotic ribosome biogenesis. For more than 50 years ribosomes are a major research topic. Our knowledge about ribosome biogenesis and function such as transcription, mRNA modification, and translation was the sine qua non for developing the powerful RNA-based vaccines against RNA-viruses causing the world-threatening Covid-19 pandemia. The chapters in this book are organized into six parts. Part One discusses a comparative survey about the unity and diversity of ribosome biogenesis in pro- and eukaryotic cells. Part Two deals with the genomic organization of eukaryotic rDNA and the role of RNA polymerase I in ribosomal RNA transcription. Part Three explores in vitro methods to study RNA polymerase I structure and its function, and Part Four analyzes the nucleo-cytoplasmic transport of assembled ribosomes and RNP complexes. Part Five covers modifications that increase the complexity of rRNAs, and Part Six provides readers with a review of eukaryotic translation and - for the first time - describes a new method to analyze translation in vitro. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Ribosome Biogenesis: Methods and Protocols is a valuable resource for scientists and researchers interested in learning more about the increasing importance of in vitro RNA-technologies.
Life from an RNA World
Life from an RNA World - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Life from an RNA World write by Michael Yarus. This book was released on 2010. Life from an RNA World available in PDF, EPUB and Kindle. A majority of evolutionary biologists believe that we now can envision our biological predecessors--not the first, but nearly the first, living beings on Earth. This book is about these vanished forebears. The era between the first rudimentary life on Earth and the appearance of more complex beings is called the RNA world. It is RNA (ribonucleic acid) long believed to be a mere biologic copier and messenger, that offers a glimpse into our ancient predecessors. To describe early RNA creatures, here called "ribocytes" or RNA cells, the author uses basics of molecular biology. He reviews our current understanding of the tree of life, examines the structure of RNA itself, explains the operation of the genetic code, and more. Courting controversy among those who question the role of ribocytes -- citing the chemical fragility of RNA and the uncertainty about the origin of an RNA synthetic apparatus -- he offers a vision of early life on Earth.
