Stability and Characterization of Protein and Peptide Drugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Stability and Characterization of Protein and Peptide Drugs write by Rodney Pearlman. This book was released on 2013-06-29. Stability and Characterization of Protein and Peptide Drugs available in PDF, EPUB and Kindle. This is the first volume to make available specific case histories of therapeutic proteins and peptides that have been marketed or are currently under clinical testing. The editors have selected a wide range of molecules derived from monoclonal antibodies, recombinant DNA, and natural and chemical sources to provide formulation scientists with practical examples of the development of pharmaceutical products.
Formulation, Characterization, and Stability of Protein Drugs
Formulation, Characterization, and Stability of Protein Drugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Formulation, Characterization, and Stability of Protein Drugs write by Rodney Pearlman. This book was released on 2006-04-11. Formulation, Characterization, and Stability of Protein Drugs available in PDF, EPUB and Kindle. Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential `hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.
Physical Methods to Characterize Pharmaceutical Proteins
Physical Methods to Characterize Pharmaceutical Proteins - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Physical Methods to Characterize Pharmaceutical Proteins write by James N. Herron. This book was released on 2013-11-21. Physical Methods to Characterize Pharmaceutical Proteins available in PDF, EPUB and Kindle. Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable interest from both industrial and aca demic environments, forcing pharmaceutical scientists to explore a domain previ ously examined only by peptide and protein chemists. Biopharmaceutical aspects of proteins, e.g., low oral bioavailability, have been extensively investigated. Although all possible conventional routes of ad ministration have been examined for proteins, no real, generally applicable alter native to parenteral administration in order to achieve systemic effects has yet been discovered. Several of these biopharmaceutical options have been discussed in Volume 4 of this series, Biological Barriers to Protein Delivery. Proteins are composed of many amino acids, several of which are notorious for their chemical instability. Rational design of formulations that optimize the native structure and/or bioactivity of a protein is therefore of great importance when long shelf life is required, as it is for pharmaceutical products. This issue has also been examined in two prior volumes of this series: Volume 2: Stability of Protein Pharmaceuticals (Part A) and Volume 5: Stability and Characterization of Protein and Peptide Drugs.
Protein Formulation and Delivery
Protein Formulation and Delivery - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protein Formulation and Delivery write by Eugene J. McNally. This book was released on 2007-10-26. Protein Formulation and Delivery available in PDF, EPUB and Kindle. This title is intended to assist pharmaceutical scientists in the development of stable protein formulations during the early stages of the product development process, providing a comprehensive review of mechanisms and causes of protein instability in formulation development, coverage of accelerated stability testing methods and relevant analytica
Peptide and Protein Drug Analysis
Peptide and Protein Drug Analysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Peptide and Protein Drug Analysis write by Ronald Reid. This book was released on 1999-11-12. Peptide and Protein Drug Analysis available in PDF, EPUB and Kindle. Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry demonstrates uses of unnatural mutagenesis and combinatorial chemistry explores mass spectrometry, protein sequence, and carbohydrate analysis illustrates bioassays and other new functional analysis methods surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.
