Successful Strategies for the Discovery of Antiviral Drugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Successful Strategies for the Discovery of Antiviral Drugs write by Manoj C. Desai. This book was released on 2013-06-17. Successful Strategies for the Discovery of Antiviral Drugs available in PDF, EPUB and Kindle. The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been approved, and in the next few years many individual drugs and single tablet regimens will be approved for the treatment of hepatitis C virus infection. The increasing success in the antiviral area could be due to targeting drugs at "non-self" genomes and to the patient population that is tolerant of manageable side effects and adaptable to inconvenient dosing. Aimed at medicinal chemists and emerging drug discovery scientists, the book is organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. This book focuses on capturing tactical aspects of problem solving in antiviral drug design, an approach that holds special appeal for those engaged in antiviral drug development, but also appeals to the broader medicinal chemistry community based on its focus on tactical aspects of drug design.
Antiviral Strategies
Antiviral Strategies - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Antiviral Strategies write by Hans-Georg Kräusslich. This book was released on 2008-12-02. Antiviral Strategies available in PDF, EPUB and Kindle. A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.
Successful Strategies for the Discovery of Antiviral Drugs
Successful Strategies for the Discovery of Antiviral Drugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Successful Strategies for the Discovery of Antiviral Drugs write by Manoj C. Desai. This book was released on 2013. Successful Strategies for the Discovery of Antiviral Drugs available in PDF, EPUB and Kindle. This volume will be aimed at medicinal chemistry and emerging drug discovery scientists.
Human Herpesviruses
Human Herpesviruses - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Human Herpesviruses write by Ann Arvin. This book was released on 2007-08-16. Human Herpesviruses available in PDF, EPUB and Kindle. This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Viral Pathogenesis
Viral Pathogenesis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Viral Pathogenesis write by Michael G. Katze. This book was released on 2015-12-30. Viral Pathogenesis available in PDF, EPUB and Kindle. Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. - Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis - Provides a fresh perspective on the approaches used to understand how viruses cause disease - Features molecular profiling techniques, whole genome sequencing, and innovative computational methods - Highlights the use of contemporary approaches and the insights they provide to the field
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