Surrogate Tissue Analysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Surrogate Tissue Analysis write by Michael E. Burczynski. This book was released on 2005-11-10. Surrogate Tissue Analysis available in PDF, EPUB and Kindle. Despite rapidly expanding interest in potential applications of surrogate tissue analysis and intense competition to identify and validate biomarkers in appropriate surrogate tissues, very few peer reviewed publications describing the use of this approach have appeared in the scientific press. One of the first publications on this topic, Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches describes initial applications and considerations for "omic" technologies in the field of surrogate tissue analysis. Highlighting important issues to consider when conducting profiling studies to identify novel biomarkers, the first section covers transcriptional approaches in surrogate tissues. It provides a review of important issues in peripheral blood profiling, summarizes results achieved when evaluations of various blood preparation platforms are used for the purpose of transcriptional profiling, and covers the relatively novel application of transcriptional profiling in neurological and oncological disease settings. The second section focuses on proteomic and protein-based methods for identifying markers in surrogate tissues, highlighting immunoassay and mass-spectrometry approaches for assessment of proteins in serum and other fluids, with a focus on the implications of protein-based biomarkers for detecting and monitoring early stages of cancer. The third section explores metabolomic approaches along with other novel molecular screens that can be applied in surrogate tissues to find biomarkers, and examines in detail the rapid development of metabolomics into a powerful technique for biomarker identification. The authors conclude with coverage of regulatory considerations, economic impact, and pan-omic strategies which will undoubtedly impact surrogate tissue analysis in the future. They explore current concepts in pan-omic approaches during drug development where a compendium of data generated by multiple profiling approaches are assessed and evaluated with its impact on the field of systems biology. The last chapter rounds out the coverage with a brief look ahead towards future analytical issues that will likely arise in the field of surrogate tissue analysis. The book is both an introduction to the various "omic" technologies in this young field and a fundamental reference for scientists interested in identifying biomarkers in surrogate tissues.
Surrogate Tissue Analysis
Surrogate Tissue Analysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Surrogate Tissue Analysis write by Michael E. Burczynski. This book was released on 2005-11-10. Surrogate Tissue Analysis available in PDF, EPUB and Kindle. Both an introduction and a fundamental reference, this book explores how to apply genomic, proteomic, and metabolomic technologies to surrogate tissue analysis. It reviews fundamental analytical issues and actual initial results generated using these technologies. The book covers transcriptional profiling (genomics), protein profiling (proteomics), methylation profiling (epigenomics), metabolite profiling (metabolomics) and additional biomarker identification methods that can be applied to surrogate tissues. This book is useful to researchers and scientists interested in applying novel methodologies for identifying biomarkers in the fields of pharmacology, toxicology, and medicine.
Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease
Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease write by Institute of Medicine. This book was released on 2010-06-25. Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease available in PDF, EPUB and Kindle. Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
Biomarkers for Traumatic Brain Injury
Biomarkers for Traumatic Brain Injury - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biomarkers for Traumatic Brain Injury write by Svetlana Dambinova. This book was released on 2012. Biomarkers for Traumatic Brain Injury available in PDF, EPUB and Kindle. Due to injuries sustained in sports and in combat, interest in traumatic brain injury (TBI) has never been greater. This book will fulfill a gap in understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging.
Clinical Labor
Clinical Labor - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Clinical Labor write by Melinda Cooper. This book was released on 2014-01-22. Clinical Labor available in PDF, EPUB and Kindle. Forms of embodied labor, such as surrogacy and participation in clinical trials, are central to biomedical innovation, but they are rarely considered as labor. Melinda Cooper and Catherine Waldby take on that project, analyzing what they call "clinical labor," and asking what such an analysis might indicate about the organization of the bioeconomy and the broader organization of labor and value today. At the same time, they reflect on the challenges that clinical labor might pose to some of the founding assumptions of classical, Marxist, and post-Fordist theories of labor. Cooper and Waldby examine the rapidly expanding transnational labor markets surrounding assisted reproduction and experimental drug trials. As they discuss, the pharmaceutical industry demands ever greater numbers of trial subjects to meet its innovation imperatives. The assisted reproductive market grows as more and more households look to third-party providers for fertility services and sectors of the biomedical industry seek reproductive tissues rich in stem cells. Cooper and Waldby trace the historical conditions, political economy, and contemporary trajectory of clinical labor. Ultimately, they reveal clinical labor to be emblematic of labor in twenty-first-century neoliberal economies.
