Synthesis of Alanyl and Homoalanyl Peptide Nucleic Acids as a Model System for Base Pairing and Use as a Catalyst - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Synthesis of Alanyl and Homoalanyl Peptide Nucleic Acids as a Model System for Base Pairing and Use as a Catalyst write by Jinhua Zhang. This book was released on 2004. Synthesis of Alanyl and Homoalanyl Peptide Nucleic Acids as a Model System for Base Pairing and Use as a Catalyst available in PDF, EPUB and Kindle.
Inhibitors of Protein–Protein Interactions
Inhibitors of Protein–Protein Interactions - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Inhibitors of Protein–Protein Interactions write by Ali Tavassoli. This book was released on 2020-12-07. Inhibitors of Protein–Protein Interactions available in PDF, EPUB and Kindle. Protein-protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.
Frontiers of Astrobiology
Frontiers of Astrobiology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Frontiers of Astrobiology write by Chris Impey. This book was released on 2012-11-15. Frontiers of Astrobiology available in PDF, EPUB and Kindle. Investigating the latest research questions in astrobiology, this volume will fascinate a wide interdisciplinary audience at all levels.
Biochemistry of Cell Walls and Membranes in Fungi
Biochemistry of Cell Walls and Membranes in Fungi - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biochemistry of Cell Walls and Membranes in Fungi write by Paul J. Kuhn. This book was released on 2012-12-06. Biochemistry of Cell Walls and Membranes in Fungi available in PDF, EPUB and Kindle. Despite the many advances made during the last decade in various aspects of fungal biochemistry, there have been very few volumes devoted to the sub ject in recent years. This lack is all the more surprising in view of the increas ing use of fungi in gene manipulation studies and in biotechnological ap plications, and of the current interest in the biorational discovery of novel agents for the control of fungal pathogens of plants and humans. We hope that this book goes some way to rectifying this situation by providing an up to-date account of selected developments in two important areas, namely cell walls and membranes. Topics included in the book concern both yeasts and filamentous fungi. Although the main emphasis is on biogenesis, functional aspects are also discussed, e.g. the role of glycoproteins in recognition of sterols in mem branes and of calcium in regulation. Several contributions describe in terference with the 'normal' biochemistry of cell walls and membranes with a view to increasing fundamental knowledge, but also highly relevant to the design of new fungicides and antimycotics. The steadily increasing impact of molecular biology on the study of fungal biochemistry is highlighted throughout.
G-Quadruplex DNA
G-Quadruplex DNA - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook G-Quadruplex DNA write by Peter Baumann. This book was released on 2016-08-23. G-Quadruplex DNA available in PDF, EPUB and Kindle. Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In "G-Quadruplex DNA: Methods and Protocols", experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, "G-Quadruplex DNA: Methods and Protocols "promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA.
