The Biology of Oligodendrocytes - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Biology of Oligodendrocytes write by Patricia Armati. This book was released on 2010-10-21. The Biology of Oligodendrocytes available in PDF, EPUB and Kindle. Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.
Oligodendrocytes
Oligodendrocytes - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Oligodendrocytes write by David A. Lyons. This book was released on 2019-03-01. Oligodendrocytes available in PDF, EPUB and Kindle. This volume looks at the study of oligodendrocytes through in vitro and in vivo techniques, multiple model organisms, using approaches that bridge scales from molecular through system. Chapters in this book cover topics such as fundamental molecular analyses of oligodendrocytes and myelin; in vitro, ex vivo, and in vivo molecular-cellular-electrophysiology-based techniques; oligodendrocyte formation, homeostasis, and disruption in zebrafish and Xenopus; and parallel system-level imaging of animal and human models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Oligodendrocytes: Methods and Protocols is a valuable reference guide that highlights the expansive and fast-paced nature of research into oligodendrocyte biology underlying health and function.
Oligodendrocytes
Oligodendrocytes - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Oligodendrocytes write by Dana Swanson. This book was released on 2015. Oligodendrocytes available in PDF, EPUB and Kindle. Oligodendrocytes have multiple functions in the central nervous system including mechanical support of neurons, production of myelin sheaths and uptake and inactivation of chemical neurotransmitters released by neurons. Consequently, oligodendrocytes could be involved in the pathology of a number of neurodegenerative diseases. The first chapter of this book examines the range of disorders in which oligodendrocytes play a significant role. In the second chapter, the authors review the effects of microglia on oligodendrocytes in both physiological and pathological conditions. The third chapter focuses on cell transplantation for myelination of axons in spinal cord repair. In the fourth chapter, the authors review data showing the induction of some plasticity of olidogdendrocytes (OL) by growth factors and axon proteins in vitro. Finally, the last chapter is an examination of the potential uses of anti-S100B therapies to treat myelin-related disorders in order to reduce damage and improve recovery, as well as the quality of life of these patients.
Neuroimmune Pharmacology
Neuroimmune Pharmacology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Neuroimmune Pharmacology write by Tsuneya Ikezu. This book was released on 2016-12-22. Neuroimmune Pharmacology available in PDF, EPUB and Kindle. The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.
The Glutamate/GABA-Glutamine Cycle
The Glutamate/GABA-Glutamine Cycle - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Glutamate/GABA-Glutamine Cycle write by Arne Schousboe. This book was released on 2016-11-25. The Glutamate/GABA-Glutamine Cycle available in PDF, EPUB and Kindle. Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.
