The Carbonic Anhydrases: Current and Emerging Therapeutic Targets - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Carbonic Anhydrases: Current and Emerging Therapeutic Targets write by W. Richard Chegwidden. This book was released on 2021-10-30. The Carbonic Anhydrases: Current and Emerging Therapeutic Targets available in PDF, EPUB and Kindle. This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
The Carbonic Anhydrases: Current and Emerging Therapeutic Targets
The Carbonic Anhydrases: Current and Emerging Therapeutic Targets - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Carbonic Anhydrases: Current and Emerging Therapeutic Targets write by W. Richard Chegwidden. This book was released on 2021. The Carbonic Anhydrases: Current and Emerging Therapeutic Targets available in PDF, EPUB and Kindle. This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development
Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development write by Kunal Roy. This book was released on 2023-05-23. Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development available in PDF, EPUB and Kindle. Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development aims at showcasing different structure-based, ligand-based, and machine learning tools currently used in drug design. It also highlights special topics of computational drug design together with the available tools and databases. The integrated presentation of chemometrics, cheminformatics, and machine learning methods under is one of the strengths of the book.The first part of the content is devoted to establishing the foundations of the area. Here recent trends in computational modeling of drugs are presented. Other topics present in this part include QSAR in medicinal chemistry, structure-based methods, chemoinformatics and chemometric approaches, and machine learning methods in drug design. The second part focuses on methods and case studies including molecular descriptors, molecular similarity, structure-based based screening, homology modeling in protein structure predictions, molecular docking, stability of drug receptor interactions, deep learning and support vector machine in drug design. The third part of the book is dedicated to special topics, including dedicated chapters on topics ranging from de design of green pharmaceuticals to computational toxicology. The final part is dedicated to present the available tools and databases, including QSAR databases, free tools and databases in ligand and structure-based drug design, and machine learning resources for drug design. The final chapters discuss different web servers used for identification of various drug candidates. - Presents chemometrics, cheminformatics and machine learning methods under a single reference - Showcases the different structure-based, ligand-based and machine learning tools currently used in drug design - Highlights special topics of computational drug design and available tools and databases
Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications write by Susan C. Frost. This book was released on 2013-10-22. Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications available in PDF, EPUB and Kindle. The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.
Carbonic Anhydrase
Carbonic Anhydrase - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Carbonic Anhydrase write by Claudiu T. Supuran. This book was released on 2004-05-27. Carbonic Anhydrase available in PDF, EPUB and Kindle. Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in
