The Drosophila Model in Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Drosophila Model in Cancer write by Wu-Min Deng. This book was released on 2019-09-13. The Drosophila Model in Cancer available in PDF, EPUB and Kindle. This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.
Drosophila Models for Human Diseases
Drosophila Models for Human Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drosophila Models for Human Diseases write by Masamitsu Yamaguchi. This book was released on 2018-06-27. Drosophila Models for Human Diseases available in PDF, EPUB and Kindle. Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
The Drosophila Model of Cancer
The Drosophila Model of Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Drosophila Model of Cancer write by Takeshi Shimizu. This book was released on 2006. The Drosophila Model of Cancer available in PDF, EPUB and Kindle.
Drosophila melanogaster
Drosophila melanogaster - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drosophila melanogaster write by Farzana Khan Perveen. This book was released on 2018-02-28. Drosophila melanogaster available in PDF, EPUB and Kindle. This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.
Transgenic Drosophila as a Drugscreening Tool in Multiple Cancers
Transgenic Drosophila as a Drugscreening Tool in Multiple Cancers - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Transgenic Drosophila as a Drugscreening Tool in Multiple Cancers write by John Rozehnal. This book was released on 2017. Transgenic Drosophila as a Drugscreening Tool in Multiple Cancers available in PDF, EPUB and Kindle. Introduction: The selection of appropriate anticancer drugs in patients is a great challenge in cancer treatment. As medicine seeks to understand the difference between the “average” tumor and a tumor in an individual patient, there is great uncertainty regarding the effect of particular genes and drugs that target them. Transgenic Drosophila melanogaster has been proposed as a rapid and efficient system in which to generate a reliable model of an individual tumor and phenotypic screen for effective drugs. Such screens can potentially lead to the identification of a molecule that modifies a cancer phenotype by acting on a previously undescribed target or by acting simultaneously on more than one target.Methods: 97 Patients were assessed for genomic and clinical data. 12 patients had tumor genetics analyzed and models created that comprised driver mutations. 3 models were attempted in Drosophila and tested against 19 anticancer drugs.Results: 1 of 3 models was technically successful and advanced to drug screening. 5 drugs (gemcitabine, trametinib, crizotinib, doxorubicin, docetaxel) were predicted by the model to be effective against that particular cancer. However, neither of the two drugs used in the corresponding patient were predicted to be successful.Conclusions: While this project was unable to concretely validate the Drosophila modeling approach by accurately predicting treatment outcomes. I was able to develop and advance methods to predict the effects of a gene within a tumor and to develop one complete Drosophila model that responded to anticancer drugs in a dose-dependent manner. Further research is needed to assess the predictive value of these models.
