The Implication of Adenylyl Cyclase Isoform 8 and Its Regulation by the Notch Pathway in Vascular Smooth Muscle Cell Transdifferentiation and Pathological Vesel Remodeling - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Implication of Adenylyl Cyclase Isoform 8 and Its Regulation by the Notch Pathway in Vascular Smooth Muscle Cell Transdifferentiation and Pathological Vesel Remodeling write by Zela Talar Keuylian. This book was released on 2013. The Implication of Adenylyl Cyclase Isoform 8 and Its Regulation by the Notch Pathway in Vascular Smooth Muscle Cell Transdifferentiation and Pathological Vesel Remodeling available in PDF, EPUB and Kindle. Atherosclerosis is characterized by the narrowing of the arterial lumen termed "stenosis", due to the expansion of arterial plaques. One of the major contributing factors to the formation of lesions and the neo-intima during post-angioplasty restenosis is the phenotypic change of medial vascular smooth muscle cells. This process switches them from a quiescent/contractile phenotype to a secretory, proliferative, migratory one. My work consisted of elucidating some of the molecular mechanisms implicated in this switch. We showed that the expression of an adenylyl cyclase (AC) isoform, AC8, is implicated in both the inflammatory and migratory properties acquired by trans-differentiated VSMCs. In human atherosclerotic arteries we showed that only intimal VSMCs strongly express AC8; very few AC8 positive VSMCs were detected in the medial layer, either in atherosclerotic or healthy arteries. In the rat balloon injury model of restenosis, we showed a transitory increase of AC8 expression. In vitro, we demonstrated that AC8 expression is regulated by the Notch pathway; inhibiting Notch amplified AC8 expression and decreased Notch target genes Hrt1 and Hrt3. In the same model of restenosis, the transitory up-regulation of AC8 expression coincided with Notch3 down-regulation. These set of experiments demonstrated that the Notch pathway decreases IL1[beta]-mediated AC8 up-regulation in trans-differentiated VSMCs and suggests that AC8 expression, besides being induced by the proinflammatory cytokine IL1[beta],also depends on the down-regulation of the Notch pathway occurring in an inflammatory context. As a whole, my studies attribute a new role for AC8 in pathological vascular remodeling.
Textbook of Vascular Medicine
Textbook of Vascular Medicine - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Textbook of Vascular Medicine write by Rhian M. Touyz. This book was released on 2019-08-02. Textbook of Vascular Medicine available in PDF, EPUB and Kindle. This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Sirolimus-Eluting Stents
Sirolimus-Eluting Stents - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Sirolimus-Eluting Stents write by Patrick W. Serruys. This book was released on 2004-11-29. Sirolimus-Eluting Stents available in PDF, EPUB and Kindle. Recently, sirolimus-eluting stents implantation has been shown to decrease restenosis markedly in selected patients. Nonetheless, the effects of SES implantation in complex, unselected patients, such as those commonly treated in daily practice ('the real world'), remains largely unknown. This book comprehensively evaluates the impact of SES implantation on the outcomes of patients treated in the real world of interventional cardiology. The authors have evaluated in detail the short- and long-term outcomes of several high-risk subsets not currently included in randomized trials. While it is specific to sirolimus, the book covers the major competing drug eluting stents, including paclitaxel.
PanVascular Medicine
PanVascular Medicine - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook PanVascular Medicine write by Peter Lanzer. This book was released on 2015-03-30. PanVascular Medicine available in PDF, EPUB and Kindle. Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.
Vascular Effects of Hydrogen Sulfide
Vascular Effects of Hydrogen Sulfide - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Vascular Effects of Hydrogen Sulfide write by Jerzy Bełtowski. This book was released on 2019-05-30. Vascular Effects of Hydrogen Sulfide available in PDF, EPUB and Kindle. This book explores techniques for exploring hydrogen sulfide (H2S) and its effects on the vascular system through numerous experimental animal models and vascular preparations. Alterations of vascular H2S generation/signaling may be involved in the pathogenesis of systemic and pulmonary arterial hypertension, ischemic heart disease, ischemic stroke, preeclampsia, and erectile dysfunction, and H2S also serves as an attractive target for pharmacotherapy of cardiovascular diseases, as well as possible effects on cancer, wound healing, and diabetic retinopathy, among other pathologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vascular Effects of Hydrogen Sulfide: Methods and Protocols is an ideal aid for scientists working to extend our knowledge in this valuable and wide-ranging field of study.
