Proteasome Inhibitors in Cancer Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Proteasome Inhibitors in Cancer Therapy write by Julian Adams. This book was released on 2004-05-25. Proteasome Inhibitors in Cancer Therapy available in PDF, EPUB and Kindle. A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.
The Proteasome — Ubiquitin Protein Degradation Pathway
The Proteasome — Ubiquitin Protein Degradation Pathway - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Proteasome — Ubiquitin Protein Degradation Pathway write by Peter Zwickl. This book was released on 2012-12-06. The Proteasome — Ubiquitin Protein Degradation Pathway available in PDF, EPUB and Kindle. This volume gives an overview of pro tea some-mediated protein degradation and the regulatory role of the ubiquitin system in cellular proteolysis. The first chapter describes the molecular evolution of the proteasome and its associated activators, i. e. , the 20S core, the base and the lid of the 19S cap, and the 11 S regulator. The ensuing chapter gives an overview of the structure and assembly of the 20S proteasome and the regulation of the archaeal proteasome by PAN. The third contribution summarizes our knowledge on the eukaryotic 26S proteasome and its regulation by the 19S regu lator, followed by a chapter devoted to the llS regulator, which elucidates the structural basis for the 11 S-mediated activation of the 20S proteasome. The fifth chapter reviews in detail the role of the proteasome in the immune response. The subsequent chapter of the natural substrates of the gives a comprehensive description proteasome and their recognition by the enzymes of the ubiqui tination machinery. The penultimate chapter rounds up the in formation on intracellular distribution of proteasomes in yeast and mammalian cells, while the last contribution highlights proteasome inhibitors, tools which proved to be very valuable for dissecting the cellular roles of the proteasome and which might turn out to be of pharmacological importance.
Ubiquitin and the Biology of the Cell
Ubiquitin and the Biology of the Cell - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Ubiquitin and the Biology of the Cell write by Jan-Michael Peters. This book was released on 1998-05-31. Ubiquitin and the Biology of the Cell available in PDF, EPUB and Kindle. The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.
Cell Biology by the Numbers
Cell Biology by the Numbers - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cell Biology by the Numbers write by Ron Milo. This book was released on 2015-12-07. Cell Biology by the Numbers available in PDF, EPUB and Kindle. A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid
The Ubiquitin System
The Ubiquitin System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Ubiquitin System write by Milton J. Schlesinger. This book was released on 1988. The Ubiquitin System available in PDF, EPUB and Kindle.
